Sah awarded $2.06M grant

Rajan Sah, MD, PhD

Rajan Sah, MD, PhD

Rajan Sah, MD, PhD, assistant professor of cardiovascular medicine, has received an RO1 grant for $2.06 million from the National Institutes of Health entitled, “Tuning fat cell size and obesity through SWELL1.”

Dr. Sah’s proposal seeks to address a fundamental question that impacts our understanding of the obesity epidemic namely: What are the mechanisms engineered into the fat cell (adipocyte) that permit its remarkable ability to expand by up to 30 times its original size? His project will determine if there are cellular “stretch” sensors active within the adipocyte to respond to such massive changes in cell size.

Answering these questions will shed new light on the basic biology of fat storage, the pathophysiology of obesity, and will potentially identify novel therapeutic targets for the prevention of obesity and associated diseases such as diabetes.