Dr. Ebach Participates in Community Education

Dr. Dawn Ebach (in green) and other guest speakers

Dr. Dawn Ebach, Clinical Professor from the Division of Gastroenterology, Hepatology, Pancreatology and Nutrition, presented on inflammatory bowel disease (IBD) at the CCF Patient Education Seminar at the Coralville Public Library on May 4, 2019.

Congratulations, Dr. Ebach on all your education efforts, both inside and outside the hospital!

Dr. Widness Publishes on Erythropoietin in Premature Infants

Congratulations to Dr. Jack Widness (professor emeritus, Neonatology) and his research team on their recent publication in the Journal of Clinical Pharmacology.

D’Cunha R, Widness JA, Yan X, Schmidt RL, Veng-Pedersen P, An G. A Mechanism-Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses. Journal of Clinical Pharmacology 2019, 59(6) 835–846.

Abstract: The objective of the current study was to develop a population pharmacokinetics (PK) model for erythropoietin (Epo) in premature infants and healthy adults to characterize the variation in PK, and to study the differences in Epo PK in these 2 populations. Thirteen very low-birth-weight premature infants (<1500 g at birth), and 10 healthy adults received up to 4 intravenous doses of Epo that ranged from 10 to 500 U/kg. The final model had a target-mediated saturable, nonlinear, elimination pathway that incorporated the mechanism of Epo binding to its receptors along with a parallel linear, central elimination pathway. Epo clearance was found to be significantly higher in preterm infants compared to adults. Epo clearance via the nonlinear pathway was found to be much higher in infants; they had an Epo receptor capacity of 133 pM vs 86.6 pM in adults, which is most likely due to the higher erythroid progenitor cell mass per kilogram of body weight in infants. The parallel linear elimination was found to be more dominant in adults, reaching 91% of the total clearance with a 500-U/kg dose compared to just 6.1% of the total clearance following the same dose in preterm infants. Thus, this mechanism-based population PK model revealed that receptor-based nonlinear elimination is the dominant Epo elimination pathway in premature infants, and parallel linear elimination is dominant in adults.

Dr. Tsalikian Named Interim Chair/DEO Beginning June 2

The College of Medicine has announced that Eva Tsalikian, MD, will serve as interim chair and departmental executive officer (DEO) of the Stead Family Department of Pediatrics, effective June 2, 2019. As part of this role, she will also assume duties as interim Physician-in-Chief of University of Iowa Stead Family Children’s Hospital.

Dr. Tsalikian is currently director of the Division of Pediatric Endocrinology and Diabetes and Vice Chair for Clinical Affairs for the Stead Family Department of Pediatrics.

Dr. Tsalikian, a Professor of Pediatrics, joined the faculty of the Carver College of Medicine in 1983. She served as Chief of Staff for UI Hospitals & Clinics from 2006 to 2012. Her research primarily focuses on the causes, effects, treatment and prevention of Type 1 diabetes in children and adolescents. Dr. Tsalikian will succeed Raphael Hirsch, MD, who has served as chair and DEO of the Department, as well as Physician-in-Chief of the children’s hospital since 2012. He is leaving to take similar posts at Benioff Children’s Hospital and University of California-San Francisco. His final day at Iowa is June 1, 2019.

A national search for a replacement will be co-chaired by Janet Fairley, MD, Chair of the Department of Dermatology, and Lois Geist, MD, MS, Associate Dean for Faculty Affairs and Development. More information about the search will be forthcoming.

Staff Spotlight – Shruti Tewar, MBBS

Dr. Tewar started in the Department in 2016 as Clinical Assistant Professor in the Division of Developmental and Behavioral Pediatrics.

My husband, Arun Modi is a Pediatric Bone Marrow Transplant physician here at UIHC. We have two adorable and energetic daughters under the age of 3. Although most of our family lives in India, we are fortunate to have grandparents come visit and spend time with us for extended time!

In my free time I like to spend it with my family, and go on walks now that the weather is getting nicer! Being a mom is a full time hobby right now :).

India is my favorite place. I grew up in India and the diversity in culture, languages, and cuisines just amazes me every time I go back.

While I see children with a wide variety of developmental and behavioral concerns, including ADHD, autism, developmental and learning disabilities, I am also interested in working closely with children with adverse childhood experiences. I do a wide variety of EPIC improvement projects for CDD and I am part of an ongoing scribe pilot project for our department. Since our wait times can be long, if you have a concern that cannot wait or needs a brief curbside opinion, please send me an email or EPIC message and I am happy to help out!

Staff Spotlight – Teresa Schmidt

Teresa currently provides administrative support to the Division of Endocrinology and Diabetes, and serves as the Fellowship Coordinator for the Division, as well.

I’m also the Interim Coordinator for Pediatric Cardiology Fellowship. I have worked at UIHC for 39 years – I started in Pediatrics from 1980-1986 and then went to Anesthesia until I returned to Pediatrics in April 2016. In Anesthesia I started as the division secretary and Coordinator for the Anesthesia Obstetrics Fellowship program, and then in 1998 was division secretary for Pain Medicine and Regional Anesthesia as well as being Fellowship Coordinator for both.

I am married to my husband John and we live in Marion. I have one son, Joe and one granddaughter, Ella who live in Coralville.

We glamp (camping, but definitely do not roughing it!). We belong to a camping club and was club president for approximately 10 years. I love to read, travel, hike, bike and family history. I also organize my family reunion each year.

My dream job is to be a genealogist – yes I am a history nerd!

The most fascinating place I’ve ever been is Alaska – my husband and I took our honeymoon in Alaska.

My favorite sports team is the Hawekeyes, and my favorite book is Sarah’s Key by Tatiana de Rosnay.

Fun fact: In my 20s I was a flag girl at a sprint car track for several years..

Staff Spotlight – Jason Misurac, MD

Dr. Misurac has been Clinical Assistant Professor in the Division of Nephrology, Dialysis, and Transplantation for 3 years; and Associate Medical Director of the Pediatric Specialty Clinic.

My children are 2 and 4 years of age, and are a constant bundle of energy and joy. My wife helps keep us all in line!

My hobbies including reading fiction, spending time with my kids both indoors and outside, camping, hiking, and biking.

I lived in Zagreb, Croatia for 6 months before starting medical school. I worked for the Croatian Medical Journal and took Croatian language classes.

I’m a long term Philadelphia Eagles fan, and my favorite book is Old Man’s War by John Scalzi.

Please Welcome Dr. McLennan to Pediatric Cardiology

Please welcome Dr. Daniel McLennan to the Stead Family Department of Pediatrics as Clinical Assistant Professor of Pediatrics.

Dr. McLennan earned his Bachelor of Medicine and Bachelor of Surgery from the University of Sydney in 2007. He then completed advanced training in pediatric cardiology in Australia until 2010 after which he went on to perform as a Pediatric Registrar until 2013. Dr. McLennan completed his categorical Pediatric Cardiology fellowship at Sydney Children’s Hospital in 2016. He was an advanced fellow at Bristol Children’s Hospital as well as in Pediatric Intensive Care at Evelina Children’s Hospital, where he managed post-surgical patients with congenital and acquired cardiac disease. Dr. McLennan is currently completing an extended specialized fellowship in Pediatric Interventional Cardiology at Children’s Hospital Colorado, Denver.

Dr. McLennan will be active as a member of the Pediatric Cardiology Clinical Service. He will perform interventional cardiology procedures, attend on the pediatric cardiology inpatient and consultation service, share on-call responsibilities, including pediatric cardiology interventional call, and helping to continue the development of the Cardiology program. He will also assist in the advancement of a pediatric and congenital heart pulmonary hypertension program.

Please join us in welcoming Dr. McLennan to the Department, University, and the community!