Children’s Miracle Network and UI Stead Family Children’s Hospital Discretionary Gift Fund requests for 2020 are open. Submission deadline is Friday, Feb. 14. Visit “Funding Requests, UI Stead Family Children’s Hospital” under “Administration and Staff” on The Point.
Research Applications: This funding opportunity is seeking high risk/high reward innovative research projects to advance/improve stem cell transplantation and/or immunotherapies for pediatric cancer patients. Both basic science and clinical intervention development projects are eligible.
Individuals who were awarded funding for a research project in 2019, are not eligible for a renewal. The instructions are attached to submit a new application.
Non-Research Applications:The UI Dance Marathon Allocations NEW
Application can be found here.
If you have not been funded by Dance Marathon in the past year, please submit
this new application by February 14th
Renewal applications: The UI Dance Marathon Allocations RENEWAL Application can
be found here.
If you currently have a project funded through this committee, please submit
this renewal application by February 14th
The Iowa Neonatal Clinical Research Committee (INCRC) was developed to promote neonatal clinical research and assist investigators who plan to recruit infants in the NICU. Infants in the Neonatal Intensive Care Unit (NICU), along with their families represent a vulnerable population in which research is needed to provide evidence for improving care. There is considerable potential for competition among studies within this population. This committee is responsible for advocating on behalf of this finite population for the conduct of high-quality clinical research for infants in the NICU, as well as facilitating quality research with these potential study participants. This interdisciplinary team provides scientific and feasibility guidance for investigators who would like to conduct research within the NICU. The INCRC reviews and facilitates protocols to ensure patient safety, dignity, and satisfaction with the goal of minimal disruption in the typical functioning of the NICU.
Dr. Hatem El-Shanti was chosen as one of four selected researchers, chosen by Dean Jackson, to present on his research efforts at the upcoming event Spotlight on Current and Future Research. This event will feature 4 presenters giving a short-talk seminar about their research and how it’s breaking new ground in their field.
The event is Monday, December 2, from 4:00-5:00 PM in 1459 PBDB.
For more than 20 years the Pediatric Diabetes Research Group at the University of Iowa has studied pediatric Type 1 diabetes, and more recently Type 2 diabetes and Cystic Fibrosis-Related Diabetes with clinical studies and trials.
Pivotal studies on continuous glucose monitoring, on prevention of diabetes in relatives of type 1 diabetes patients, on immune modulation of new onset Type 1 diabetes have been performed as part of consortiums funded federally or from foundations such as the Juvenile Diabetes Research Foundation and the Helmsley Foundation. In addition, the group has been part of a five clinical center NIH funded consortium studying hypoglycemia prevention in Type 1 diabetes and most recently performed neuroanatomical and neurocognitive studies evaluating the effect of hyper and hypoglycemia on the developing brain of young children with Type 1 diabetes. Findings have been original and unprecedented in literature. See here and here.
Clinical trials conducted by the group in adolescents with Type 2 diabetes have led to identifying appropriate pharmacologic approaches for this recently common adolescent disease.
In recent years, Dr. Katie Larson-Ode has joined the group and her studies have identified abnormal glucose metabolism in young children with Cystic Fibrosis. This finding has led to multiple clinical studies with impactful outcomes and funding by the Cystic Fibrosis Foundation for a multicenter consortium to conduct pivotal studies in these young children. Dr. Larson Ode and the Pediatric Diabetes Research Group are one of the clinical centers and the coordinating center for the consortium.
Congratulations to Dr. Staber for her recent new grant received from the National Hemophilia Foundation for “Understanding of a Neurophenotype in Hemophilia A“. The grant provides $125,000 over one year.
Congratulations to Dr. Catherina Pinnaro (fellow in Endocrinology) for her recent $2,000 grant from the Lawson Wilkins Pediatric Endocrine Society. The funds will go towards studying “Genetic Modifiers of Glycemic Variability and CHD in Tumer Syndrome“.
The central administrative research support team for both bench and clinical research has moved from their previous space in GH SW 164-4 to BT 1115. BT 1115 is the space that also houses the Dunphy Conference Room.
Team members who have moved include Dan Benton, Lindsey Eckrich, Donna Friel and Angi Roemerman.
Background: Preterm infants are susceptible to unique pathology due to their immaturity. Mouse models are commonly used to study immature intestinal disease, including necrotizing enterocolitis (NEC). Current NEC models are performed at a variety of ages, but data directly comparing intestinal developmental stage equivalency between mice and humans are lacking.
Methods: Small intestines were harvested from C57BL/6 mice at 3–4 days intervals from birth to P28 (n = 8 at each age). Preterm human small intestine samples representing 17–23 weeks of completed gestation were obtained from the University of Pittsburgh Health Sciences Tissue Bank, and at term gestation during reanastamoses after resection for NEC (n = 4–7 at each age). Quantification of intestinal epithelial cell types and messenger RNA for marker genes were evaluated on both species.
Results: Overall, murine and human developmental trends over time are markedly similar. Murine intestine prior to P10 is most similar to human fetal intestine prior to viability. Murine intestine at P14 is most similar to human intestine at 22–23 weeks completed gestation, and P28 murine intestine is most similar to human term intestine.
Conclusion: Use of C57BL/6J mice to model the human immature intestine is reasonable, but the age of mouse chosen is a critical factor in model development.
The Research Development Office in the Office of the Vice President for Research, in collaboration with the Carver College of Medicine Office of Faculty Affairs and Development, would like to make you aware that Dr. John Robertson from Grant Writer’s Seminars and Workshops (GWSW) will conduct the Write Winning Grant Proposals seminar on Friday, October 25, 2019. The seminar is appropriate for faculty members, postdoctoral researchers and administrative staff who have had some exposure to writing grant applications, either through training / mentoring or personal experience. Please share this information with faculty and staff you think would benefit from this training. Additional details are below.
TITLE: Write Winning Grant Proposals
DATE: Friday, October 25, 2019
TIME: 8:30 AM – 4:30 PM (Check in opens at 7:45 AM)
PLACE: The Hilton Garden Inn, Iowa City (328 S. Clinton Street)
COST: $150/person (includes supplemental materials and lunch)
REGISTRATION DEADLINE: Friday, October 4, 2019 (close of business)