The study identifies WASp as a novel effector of nucleus-to-Golgi, cell-survival pathway triggered by IR-induced DNA damage in the cells of the hematolymphoid lineage, and proposes impaired GDR as a new etiology in the development of a “radiosensitive” form of immune dysregulation in WAS
Treatments based on differential reinforcement may inadvertently increase the recurrence of problem behavior in the face of challenges because reinforcers for appropriate behavior occur in the same context as problem behavior. The current study evaluated one potential approach to mitigating these problems with differential reinforcement treatments based on behavioral momentum theory. Specifically, appropriate behavior was trained in contexts without a history of reinforcement prior to intervening with problem behavior. Participants were 4 children with autism spectrum disorder. Treatment used telehealth to implement functional communication training (FCT) in three alternative contexts with minimal or no history of reinforcement for problem behavior before initiating FCT in the treatment context. Evaluations of the effects of treatment and tests of resurgence were conducted intermittently during treatment to evaluate maintenance. When FCT treatment was initiated in alternative contexts, initial results were comparable to more typical implementations of FCT. Resurgence was reduced to similar levels during tests of resurgence for all participants when compared to more typical previously published implementations of FCT, but clinically significant reductions in resurgence occurred more quickly in the present study. These findings support training appropriate behavior in an alternative context to mitigate the resurgence of problem behavior during differential reinforcement treatments.
Congratulations to Dr. Janice Staber (Hematology/Oncology) on two new publication recognitions through the American Society of Hematology (ASH).
First, she was named a co-author of the ASH Daily News, which is the daily publication of the ASH annual meeting which takes place December 7-10, 2019. This involves 4 separate issues over the four days of the annual meeting and features informative articles on a wide rage of Education Program sessions, Scientific Committee sessions, and abstract presentations.
Congratulations to Dr. Uc on a recent publication in the Journal of Pediatric Gastroenterology and Nutrition!
Bellin MD, Lowe M, Zimmerman MB, Wilschanski M, Werlin S, Troendle DM, Shah U, Schwarzenberg SJ, Pohl JF, Perito E, Ooi CY, Nathan JD, Morinville VD, McFerron BA, Mascarenhas MR, Maqbool A, Liu Q, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Barth B, Abu-El-Haija M, Uc A. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data from the INSPPIRE Cohort. J Pediatr Gastroenterol Nutr. 2019 Aug 27. doi: 10.1097/MPG.0000000000002482. [Epub ahead of print]