Dr. Staber Shines Bright at ASH

Congratulations to Dr. Janice Staber (Hematology/Oncology) on her recent publication highlights for the American Society of Hematology (ASH).

First, she was a contributor for an online article for the ASH Clinical News about updates in the treatment and management of hemophilia in October 2019.

Secondly, she was the author on a series of *daily* articles for the ASH Daily News, published during the annual ASH meeting December 7-10, 2019 in Orlando, FL. The articles are linked below.

Dr. Colburn Publishes in Journal of Adolescent Health

Congratulations to Dr. Michael Colburn on his recent publication in the Journal of Adolescent Health.

Colburn MD, Harris E, Lehmann C, Widdice LE, Klein MD. Adolescent Depression Curriculum Impact on Pediatric Residents’ Knowledge and Confidence to Diagnose and Manage Depression. Journal of Adolescent Health. 66(2), February 2020, Pages 240-246.

From the Abstract: In this study, few residents reported experience initiating medication or managing adolescent depression in the continuity clinic. Residents demonstrated increased self-assessed knowledge and confidence to diagnose and manage adolescent depression after participation in a case-based adolescent depression curriculum simulating patient-provider continuity. Incorporation of training on management of adolescent depression into AM rotation may be a feasible option to standardize training within pediatric residency.

Chavez Publishes on Clerkship Administrator Certificate Program

Cathy Chaves, administrator of the Pediatrics Clerkship for medical students, was recently a contributing author on a paper in Medical Education Online about the clerkship administrator certificate program. This article provides an overview of the program, how it has been evaluated, and how it continues to evolve.

Donnita Pelser, Cathy Chavez, Lindsey Allison, Virginia Cleppe & Gary L. Beck Dallaghan (2020). Professional development for clerkship administrators: a 16-year overview of the clerkship administrator certificate program. Medical Education Online, 25:1, DOI: 10.1080/10872981.2019.1710327.

Way to go, Cathy!

Dr. Fischer Authors Two Publications

Congratulations to Dr. Tony Fischer (Pulmonary Medicine) on two publications – one as lead author and one as senior author. The articles were published in Genes and Pediatric Pulmonology, respective.

Dr. Strathearn Publishes on Drug Addiction

Congratulations to Dr. Lane Strathearn (Developmental and Behavioral Pediatrics) and his research team on their recent publication in the journal Frontiers in Psychiatry.

Strathearn L, Mertens CE, Mayes L, Rutherford H, Rajhans P, Xu G, Potenza MN, Kim S. Pathways Relating the Neurobiology of Attachment to Drug Addiction. Front Psychiatry, 08 November 2019 | https://doi.org/10.3389/fpsyt.2019.00737

Abstract: Substance use disorders constitute a significant public health problem in North America and worldwide. Specifically, substance addictions in women during pregnancy or in the postpartum period have adverse effects not only on the mother, but also on mother-infant attachment and the child’s subsequent development. Additionally, there is growing evidence suggesting that parental addiction may be transmitted intergenerationally, where the child of parents with addiction problems is more likely to experience addiction as an adult. The current review takes a developmental perspective and draws from animal and human studies to examine how compromised early experience, including insecure attachment, early abuse/neglect, and unresolved trauma, may influence the development of neurobiological pathways associated with addictions, ultimately increasing one’s susceptibility to addictions later in life. We approach this from three different levels: molecular, neuroendocrine and behavioral; and examine the oxytocin affiliation system, dopamine reward system, and glucocorticoid stress response system in this regard. Increased understanding of these underlying mechanisms may help identify key targets for early prevention efforts and inform needed intervention strategies related to both insecure attachment and addiction.

Dr. Benson Publishes on Adequate Palliative Care

Congratulations to Dr. Becky Benson (General Pediatrics and Adolescent Medicine/Palliative Care) on her recent publication in the journal Pediatrics.

Levy C, Weeks KS, Benson RJ, Miller JM, Higgins J, Deutsch SA, Lantos JD. Failure to Provide Adequate Palliative Care May Be Medical Neglect. Pediatrics. 2019 Oct;144(4). pii: e20183939. doi: 10.1542/peds.2018-3939. Epub 2019 Sep 4.

Abstract: Doctors are required to notify Child Protective Services (CPS) if parents do not provide appropriate medical care for their children. But criteria for reporting medical neglect are vague. Which treatments properly fall within the realm of shared decision-making in which parents can decide whether to accept doctors’ recommendations? Which treatments are so clearly in the child’s interest that it would be neglectful to refuse them? When to report medical neglect concerns to CPS may be controversial. It would seem inhumane to allow a child to suffer because of parental refusal to administer proper analgesia. In this ethics rounds, we present a case of an adolescent with chronic pain who is terminally ill. Her parents were not adherent to recommended analgesia regimens. Her palliative care team had to decide whether to report the case to CPS.

Cifra and Tigges Publish and Receive Award

Congratulations to Christina Cifra and Cody Tigges (Critical Care) on their recent publication in the journal Diagnosis.

This work was presented as a platform presentation and was also awarded Best Quality Improvement Abstract at the recent American Academy of Pediatrics (Section on Critical Care) National Conference 2019 in New Orleans.

Dr. Vyas Publishes on Wiskott-Aldrich Syndrome

Congratulations to Dr. Yatin Vyas (Hematology/Oncology) on his recent publication in the Journal of Allergy and Clinical Immunology on Wiskott Aldrich Syndrome.

Wen KK, Han SS, Vyas YM. Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytes. J Allergy Clin Immunol. 2019 Oct 8. pii: S0091-6749(19)31263-1. doi: 10.1016/j.jaci.2019.09.026. [Epub ahead of print].

Conclusion:

The study identifies WASp as a novel effector of nucleus-to-Golgi, cell-survival pathway triggered by IR-induced DNA damage in the cells of the hematolymphoid lineage, and proposes impaired GDR as a new etiology in the development of a “radiosensitive” form of immune dysregulation in WAS

New Publication for Dr. Schieltz

Congratulations to Dr. Kelly Schieltz (Developmental and Behavioral Pediatrics) for her recent publication in the Journal of the Experimental Analysis of Behavior.

From the abstract:

Treatments based on differential reinforcement may inadvertently increase the recurrence of problem behavior in the face of challenges because reinforcers for appropriate behavior occur in the same context as problem behavior. The current study evaluated one potential approach to mitigating these problems with differential reinforcement treatments based on behavioral momentum theory. Specifically, appropriate behavior was trained in contexts without a history of reinforcement prior to intervening with problem behavior. Participants were 4 children with autism spectrum disorder. Treatment used telehealth to implement functional communication training (FCT) in three alternative contexts with minimal or no history of reinforcement for problem behavior before initiating FCT in the treatment context. Evaluations of the effects of treatment and tests of resurgence were conducted intermittently during treatment to evaluate maintenance. When FCT treatment was initiated in alternative contexts, initial results were comparable to more typical implementations of FCT. Resurgence was reduced to similar levels during tests of resurgence for all participants when compared to more typical previously published implementations of FCT, but clinically significant reductions in resurgence occurred more quickly in the present study. These findings support training appropriate behavior in an alternative context to mitigate the resurgence of problem behavior during differential reinforcement treatments.