Faculty Combine for Publication in Journal of Cystic Fibrosis

Drs. Katie Larson Ode (Endo), Aliye Uc (GI), and Andy Norris (Endo) teamed up for a collaborative article published in the Journal of Cystic Fibrosis on “Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin.”

The research suggests a mechanism by which elevated AG (acyl-ghrelin) contributes to CF hyperglycemia through inhibition of insulin secretion, an effect magnified by low GLP-1 and GIP. Interventions that lower ghrelin, ghrelin action, and/or raise GLP-1 or GIP might improve glycemia in CF.

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