Prize-winning proteins

embryo2web[io]A confocal image shows the expression pattern of transcription factors Centrosomal protein 190 (CP190) and Suppressor of Hairy-wing [Su(Hw)]—visible in red and green, respectively—in a fruit fly embryo. Pamela Geyer, PhD, professor of biochemistry, and obstetrics and gynecology, uses this model to show how these two proteins collaborate to establish DNA regulatory elements known as chromatin insulators during development, including in the early embryo. Better understanding of chromatin insulators could improve strategies for gene therapy and treatment of human disease. The image took first place in a contest at this year’s University of Iowa Health Sciences Research Week.