Dr. Michael Apicella, UI professor and head of microbiology and senior associate dean for scientific affairs, and Anthony Zaleski, research assistant in the CCOM, were recently awarded a United States patent for “Sialic Acid Permease System.”
U.S. Patent No.: 7,413,729
UIRF Case No.: 05035

Dr. Arthur Krieg, UI professor of internal medicine, recently received a patent from Turkey for “Immunostimulatory Nucleic Acids.”
Turkey Patent No.: TR 2005 03031
UIRF Case No. 0017

Dr. Fred S. Lamb, UI professor of pediatrics, recently received a United States patent for “Use of CLC3 Chloride Channel Blockers to Modulate Vascular Tone.”
U.S. Patent No.: 7,393,864
UIRF case: 99019

Dr. Arthur Krieg, UI professor of internal medicine, recently received a Japanese patent for “Immunomodulatory Oligonucleotides.”
Japanese Patent No.: 4,126,252
UIRF Case:95038

Drs. John Engelhardt, UI professor of anatomy and cell biology, and Dongsheng Duan, now at University of Missouri, recently were awarded numerous foreign patents for “Adeno-Associated Virus Vectors and Uses Thereof.”
Netherlands Patent No.: 1082444
Portugal Patent No.: 1082444
Sweden Patent No.: 1082444
Germany Patent No.: 69936778.6
Italy Patent No.: 1082444
Finland Patent No.: 1082444
Greece Patent No.: 1082444
France Patent No.: 1082444
Spain Patent No.: 1082444
Austria Patent No.: 1082444
Belgium Patent No.:1082444
Switzerland Patent No.: 1082444
Monaco Patent No.: 1082444
Great Britain Patent No.:1082444
Ireland Patent No.:1082444

UIRF Case: 98073

Dr. Arthur Krieg, UI professor of internal medicine, recently received a Brunei patent for “Immunostimulatory Nucleic Acids.”
Brunei Darussalam Patent No.: RP/42/2007
UIRF Case: 00017

Dr. Donald Macfarlane, UI professor of internal medicine, recently received a United States patent for “Methods for Inhibiting Immunostimulatory DNA Associated Responses.”
Patent No.: 7,354,711 B2
UIRF Case: 98008

Drs. Val Sheffield, the Martin and Ruth Carver Chair in Genetics, professor of pediatrics and a Howard Hughes Medical Institute investigator; Edwin Stone, the Seamans-Hauser Chair of Molecular Ophthalmology, professor of ophthalmology and visual sciences, and an HHMI investigator; Thomas Casavant, UI professor of electrical and computer engineering and biomedical engineering and director of the Center for Bioinformatics and Computational Biology; Terry Braun, UI assistant professor of biomedical engineering and ophthalmology and visual sciences and director of the Coordinated Laboratory for Computational Genomics; and Darryl Nishimura, a research scientist in pediatrics, recently received a United States patent for “Bardet-Biedl Susceptibility Gene and Uses Thereof.”
Patent No: 7,332,591 B2
UIRF case: 05004

Dr. Arthur Krieg, UI professor of internal medicine, recently received a Hong Kong patent for “Processes for Preparing Nucleic Acid Constructs.”
Patent No.: 1031097
UIRF Case: 97076

Drs. Greg Hageman, UI professor of ophthalmology and visual sciences, and Markus Kuehn, UI assistant professor of ophthalmology and visual sciences recently were awarded a United States patent for “Nucleic Acids Encoding Interphotoreceptor Matrix Proteins.”
Patent No.: 7,312,050 B2
UIRF Case: 98079

Dr. Arthur Krieg, UI professor of internal medicine, recently received an Australian patent for “Combination Motif Immune Stimulatory Oligonucleotides with Improved Activity.”
Patent No.: 2002331643
UIRF Case: 01041

Drs. Henry Paulson, UI adjunct professor of neurology; Beverly Davidson, UI professor of neurology, and physiology and biophysics; Pedro Gonzalez-Alegre; UI assistant professor of neurology; and former UI graduate student Victor Miller recently were awarded a Singapore patent for “Allele-Specific siRNA-Mediated Gene Silencing.”
Patent No.: 109361
UIRF Case: 03054

Dr. Arthur Krieg, UI professor of internal medicine, received a Samoan patent for “Immunostimulatory Nucleic Acids.”
Registration Number: 79
UIRF Case: 00017

Drs. Max T. Baker, associate professor of anesthesia, and Mohammed Naguib, professor of anesthesiology at the University of Texas MD Anderson Cancer Center, received a United States patent for “Fluorine-Substituted Alkyl Phenol Compounds and Their Uses.”
Patent Number: 7,312,250 B2
UIRF Case: 02003

Drs. Jack T. Stapleton, professor of internal medicine; Jinhua Xiang, associate research scientist; and Sarah George, assistant professor of infectious diseases at the St. Louis University School of Medicine, were awarded a United States patent for “GB Virus C and Methods of Treating Viral Infections.”
Patent Number: 7,291,723 B2
UIRF Case: 03021

Drs. Michael Apicella, professor and head of microbiology and senior associate dean for scientific affairs, and Paul Jones, resident physician at Duluth Family Medicine Residency Program, were awarded a United States patent for “Haemophilus Influenzae Sialytransferase and Methods of Use Thereof.”
Patent Number: 7,309,600 B2
UIRF Case: 02052

Dr. Arthur Krieg, UI professor of internal medicine, recently was awarded a United States patent for “Immunostimulatory Nucleic Acids.”
Patent Number: 7,271,156 B2
UIRF Case: 00017

Dr. Michael Apicella, professor and head of microbiology and senior associate dean for scientific affairs, was awarded a United States patent for “Vaccine and Method for Preventing Biofilm Formation.”
Patent Number: 7,297,340 B2
UIRF Case: 03020

Drs. Bev Davidson, Roy J. Carver Professor in Internal Medicine and professor of molecular physiology and biophysics; Paul McCray, professor of pediatrics; Maureen Donovan, associate professor of pharmaceutics; Mark Behlke, vice president of molecular genetics, Integrated DNA Technologies, Inc.; Patrick Sinn, associate research scientist; and Hong Jia, assistant research scientist; and Anthony Fischer, graduate research assistant, were awarded a United States patent for “RNA Interference In Respiratory Epithelial Cells.”
Patent Number: 7,297,786 B2
UIRF Case: 04007

Dr. Arthur Krieg, UI professor of internal medicine, recently was awarded a European patent for “Vectors and methods for Immunization of Therapeuitic Protocols.”
Patent Number: 1003531
UIRF Case: 97076

Dr. Arthur Krieg, UI professor of internal medicine, recently was awarded an ARIPO patent for “Immunostimulatory Nucleic Acids.
Patent Number: AP 1775
UIRF Case: 00017.

Drs. Arthur Krieg and Joel Kline, both UI professors of internal medicine, recently were awarded a Chinese patent for “Immunostimulatory Nucleic Acid Molecules.”
Patent Number: ZL 9797199352.1
UIRF Case: 97001

Dr. Bryce Plapp, UI professor of biochemistry, is one of the inventors recently awarded a European patent for “Autoinducer Synthase Modulating Compounds and Uses Therefor.”

Dr. Fred Lamb, UI professor of pediatrics, was awarded a U.S. patent for “Methods to Reduce the Sensitivity of Endothelially-Comprised Vascular Smooth Muscle.”

Dr. Arthur Krieg, UI professor of internal medicine, was awarded a U.S. patent for “Immunostimulatory Nucleic Acid Molecules.” He also was awarded patents from Europe, Switzerland, German, Spain, France, the United Kingdom, Ireland and Italy for “Methods Related to Immunostimulatory Nucleic Acid-Induced Interferon.”

Dr. James Bates, UI associate professor of anesthesia, was one of the inventors awarded a U.S. patent for “S-methylcysteine, S-ehtylcysteine, and Related S-alkylthiols as Antagonists to the Effects of S-nitrosothiols and Nitric Oxide.”

Drs. Douglas Trask, UI associate professor of otolaryngology-head and neck surgery, and Jonathan Bock, a resident in otolaryngology, were awarded a U.S. patent for “Methods of Inhibiting Manganese-Containing Superoxide Disumtase 2 (MNSOD).”

Dr. Arthur Krieg was awarded a New Zealand patent for “Combination Motif Immune Stimulatory Oligonucleotides with Improved Activity.”

Drs. Michael Apicella, UI professor of microbiology, and Jennifer Edwards of Columbus Children’s Research Institute recently were awarded a United States Patent for “Vaccine and Compositions for the Prevention and Treatment of Neisserial Infections.

Drs. John Engelhardt, UI professor of anatomy and cell biology, and Dongsheng Duan, now at University of Missouri, were awarded a European patent for “Adeno-Associated Virus Vectors and Uses Thereof.

Drs. Raymond Hohl, UI professor of internal medicine, and David Wiemer, UI professor of chemistry, recently were awarded a United States patent for “Geranylgeranyl Pyrophosphate Synthase Inhibitors.”

Drs. Edwin Stone, UI professor of ophthalmology and visual sciences and a Howard Hughes Medical Institute investigator, and John Fingert, UI assistant professor of ophthalmology and visual sciences, recently were awarded a Korean patent for “Diagnostics and Therapeutics for Glaucoma.”

Drs. Arthur Krieg, UI professor of internal medicine, and George Weiner, director of the Holden Comprehensive Cancer Center at the UI, recently were awarded a Hong Kong patent for “Methods and Products for Stimulating the Immune System Using Immunotherapeutic Oligonucleotides and Cytokines.”

Drs. David Elliott, UI professor of internal medicine, and Joel Weinstock, former CCOM faculty member in intenral medicine and now with Tufts-New England Medical Center, recently were awarded a United States patent for “Use of Parasitic Biological Agents for Prevention and Control of Autoimmune Diseases.”

Drs. John Engelhardt, UI professor of anatomy and cell biology, and Dongsheng Duan, now at University of Missouri, recently were awarded a Canadian patent for “Adeno-Associated Virus Vectors and Uses Thereof.”

Drs. Raymond Hohl, professor of internal medicine, and David Wiemer, UI professor of chemistry, recently were awarded a United States Patent for “Geranylgeranyl Pyrophosphate Synthase Inhibitors.”