Link: University of Iowa

Biochemists awarded Carver Collaborative Pilot Grants

Amy Lee (Molecular Physiology and Biophysics) and our own Sheila Baker have been awarded a Carver Collaborative Pilot Grant to study the trafficking of Cav1.4 voltage-gated Ca2+ channels to the ribbon synapse of photoreceptors. Cav1.4 channels are essential for transmission of signal from photoreceptors to second order neurons in the retina. Mutations in this channel lead to X-linked incomplete congenital stationary night blindness 2.

In addition to the Lee-Baker award, Lori Wallrath and Dawn Quelle (Pharmacology) were awarded a Pilot Grant to study the function of a newly identified protein that associates with chromosomes and likely regulates the epigenetic status of the genome. The protein, termed NIAM (Nuclear Interactor of ARF and Mdm2), has domains that are typically associated with chromatin remodeling and post-translational modification of histone tails. The collaboration will bring together the expertise of the Wallrath lab in chromatin biology and that of the Quelle lab in cancer biology, utilizing both Drosophila and human cells as model systems.

Congratulations to Amy, Sheila, Lori and Dawn for their outstanding proposals. Many thanks to the Roy J. Carver Trust of Muscatine, Iowa, for support of research at the Carver College of Medicine.

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