Link: University of Iowa

Posts Tagged ‘2013 Publications’

M. Spies lab featured on the July cover of Nucleic Acids Research

Friday, August 9th, 2013

Maria Spies’ lab was featured on the July cover of Nucleic Acids Research. The article entitled “Single molecule study of the CUG repeat・MBNL1 interaction and its inhibition by small molecules,” describes a single-molecule approach developed to achieve a mechanistic description of the MBNL1 RNA biomolecular recognition event and to facilitate the discovery of drugs to inhibit its formation. This method revealed a mode of inhibition whereby the ligands and MBNL1 can form a ternary complex on the toxic CUGRNA instead of competing for the same binding site. Rational design of a new RNA binding ligand with a 100-fold increase in potency over previously validated compounds highlights the power of the developed methodology. Dr. Masayoshi Honda (postdoctoral scholar with M. Spies’) has contributed to this work along with Dr. Amin Haghighat Jahromi and Professor Steve Zimmerman (University of Illinois Urabana-Champaign).

Yu published in Science

Friday, August 9th, 2013

Liping Yu and Kevin Campbell have coauthored a Science paper on the subject of discovering the functions of two new enzymes on glycosylation of alpha-dystroglycan entitled “SGK196 Is a Glycosylation-Specific O-Mannose Kinase Required for Dystroglycan Function.” The paper has been published on Science website.

M. Spies lab published as a Featured Article in the April issue of “Nucleic Acids Research”

Friday, August 9th, 2013

Maria Spies‘ lab published a Featured Article in the April issue of Nucleic Acids Research entitled “Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.” NAR’s Featured Articles represent the top 5% of papers in terms of originality, significance and scientific excellence. Dr. Tokiha Masuda-Ozawa (former postdoc with M. Spies) and Ms. Trish Hoang (former undergraduate student with M. Spies and currently a graduate student at University of Wisconsin Madison) contributed to this work.

M. Spies published in eLife

Friday, August 9th, 2013

Maria Spies pubished in the May eLife article entitled “Sequence-dependent base-pair stepping dynamics in XPD helicase unwinding.” In this article, Spies and colleagues looked under the hood of XPD helicase, a molecular motor involved in nucleotide excision repair and initiation of transcription of DNA into RNA. Other contributors include Professor Yann Chemla and Dr. Zhi Qi (University of Illinois Urbana-Champaign), and Spies’ former graduate student Dr. Rob Pugh (currently an HHMI postdoc with Professor Paul Alquist at University of Wisconsin Madison).

Geyer and Wallrath publish in Developmental Cell

Tuesday, July 2nd, 2013

Pam Geyer and Lori Wallrath have a new paper in the June issue of Developmental Cell, entitled “The Drosophila Nuclear Lamina Protein Otefin is Required for Germline Stem Cell Survival.” The article includes Lacy Barton (current graduate student with Pam Geyer) and Belinda Pinto (2009 PhD with Pam Geyer) as co-first authors, and is available online.

Fuentes group publishes in JCB

Monday, June 17th, 2013

The Fuentes group has a paper in the June edition of the Journal of Cell Biology, entitled “A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress.” Ernie Fuentes and three from his lab, including former graduate student Tyson Shepherd, former research assistant Ann Murray and former postdoc Monika Joshi published with co-authors from UNC and The Scripps Research Institute. The article is available online.

 

Plapp editor of recent special issue

Saturday, April 20th, 2013

Dr. Bryce Plapp is the Managing Guest Editor of the recently published Special Issue of Chemico-Biological Interactions, Vol 202, February 2013 with along with four associate guest editors. The 35 papers were prepared by participants of the 16th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism, held in Ploen, Germany, July 10-14, 2012.

Fuentes group featured on the March 5 cover of Structure

Thursday, March 21st, 2013

Dr. Ernie Fuentes was senior author on a study on the Tiam1 PDZ domain bound with (phos) syndecan1 (SDC1) ligands. The x-ray crystallographic studies show how the Tiam1 PDZ domain preferentially interacts with a subset of SDC proteins, while NMR studies indicate the dynamic decoupling stimulated by SDC1 phosphorylation. The findings reveal a phosphorylation-based regulation mechanism on the selection of SDC ineratome. The paper was published in the March 5 issue of Structure, along with a cover image that illustrates the syndecan intractome and how a PDZ domain selects its partner protein. The paper is also a recommended article on Faculty of 1000 Prime, and is co-authored by current and former members of the Fuentes lab including current graduate students Xu Liu (first author) and Zhen Xu, former graduate student Tyson Shepherd, and Ann Murray.