Link: University of Iowa

Ryan Sheldon receives F32 award

Ryan Sheldon, a Postdoc in the Taylor laboratory, received an F32 Postdoctoral Fellowship awarded by the National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Sheldon’s project entitled “Regulation of Hepatic Lipogenesis by a Mitochondrial Pyruvate Carrier-Citrate Carrier Axis,” addresses the major public health problem of hyperlipidemia during Type 2 Diabetes.

Excess lipid production in the liver during type 2 diabetes leads to elevated lipids in the liver and circulation, which in turn drives many diabetes associated complications. The liver can make lipids from glucose. To do this, the glucose metabolite pyruvate is imported into mitochondria, converted to citrate, and exported to the cytosol, where is it channeled into pathways for making cholesterol and fatty acids. This research project seeks to understand how the mitochondrial pyruvate carrier and mitochondrial citrate carrier work together to influence liver lipid synthesis, accumulation, and release. Success may reveal opportunities for decreasing liver and circulating lipid content, thereby improving health outcomes in type 2 diabetes.

Congratulations, Ryan!

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