Link: University of Iowa

Rpa1-L221P is a Mol Cancer Research highlight

A new paper by Cathy Hass, Lokesh Gakhar and Marc Wold on molecular and cellular characterization of Rpa1-L221P has been chosen as a Molecular Cancer Research Highlight. This allele, when heterozygous in mouse, produces genomic instability and a cancer predisposition phenotype. By producing the corresponding human allele of Rpa1, the authors were able to show that it forms a stable, nonfunctional complex that apparently inhibits overall Rpa1 function via a haploinsufficiency mechanism.

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