Link: University of Iowa

Price Lab Publishes in Molecular Cell

The Price Lab has recently published an article entitled “THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing” in Molecular Cell. Kyle Nilson, (Molecular and Cellular Biology Graduate Student) was first author of this work. Nilson et al. use THZ1, a Cdk7 inhibitor, to uncover defects in Pol II phosphorylation, co-transcriptional capping, pausing, and productive elongation. THZ1 disrupts an ordered exchange of factors after initiation, blocking capping and pausing. These results provide mechanistic insights into the anti-proliferative and super-enhancer-selective effects of THZ1 seen by others. Congrats Price Lab!

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