Link: University of Iowa

Price lab featured on the August cover of Molecular Cell

MOLCEL_59_4.c1.inddDavid Price‘s lab was featured on the August 20 cover of Molecular Cell. The article entitled “THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing,”shows how a Cdk7 inhibitor, THZ1, dramatically impacts CTD phosphorylation, co-transcriptional capping, pausing, and P-TEFb-dependent productive elongation by disrupting an ordered exchange of factors after initiation. These results provide mechanistic insights into the anti-proliferative and super-enhancer-selective effects of THZ1 seen by others. Kyle Nilson, (Molecular and Cellular Biology Graduate Student in the Price Lab) was first author of this work. John Brogie (Biochemistry Graduate Student), Michael Turek (Biochemistry Undergraduate Major), and Jiannan Guo (Former Biochemistry Postdoc, Price Lab) also contributed to this work. The cover design by Kyle Nilson features and experiment “performed” by Nicholas Mullen (Biochemistry Undergraduate Major).

The article is also featured in a preview by Drs. Frédéric Coin and Jean-Marc Egly entitiled “Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor.”

Congratulations Price Lab!!

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