Link: University of Iowa

2017 Faculty Publications

March 1st, 2018 by Maren Rogers

The Department’s 2017 publications are now in print and mostly available online.

E. Dale Abel

Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KM, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. (2017) OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO Journal. 36(14):2126-2145.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. (2017) Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nature communications. 8:14095.

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. (2017) SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nature Cell Biology. 19(5):504-517.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. (2017) DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metabolism. 25(5):1135-1146.e7.

Fidler TP, Middleton E, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. (2017) Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation, Arteriosclerosis, Thrombosis, and Vascular Biology. Arterioscler Thromb Vasc Biol. 37(9):1628-1639.

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED. (2017) Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Reports. 20(4):881-894.

Wende AR, Kim J, Holland W, Wayment BE, O’Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. (2017) Glucose transporter 4 (GLUT4) deficient hearts develop maladaptive hypertrophy in response to physiologic or pathologic stresses., American journal of physiology. Heart and circulatory physiology.

Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. (2017) Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free radical biology & medicine. 113:16-25.

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. (2017) Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission. Circulation research.

Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S. (2018) Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. Journal of molecular and cellular cardiology. 113:39-50.

Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. (2017) Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI insight. 2(24).

Ted Abel

G Kronberg, M Bridi, T Abel, M Bikson, LC Parra. (2017)  Direct current stimulation modulates LTP and LTD: activity dependence and dendritic effects. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 10:1, 51-85.

G Kronberg, M Bridi, T Abel, LC Parra. (2017) Electric Fields Boost LTP in Vitro. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 10:1, e14-e15.

JC Kreutzmann, JC Tudor, CC Angelakos, T Abel. (2017) The Impact of Sleep Deprivation on Molecular Mechanisms of Memory Consolidation in Rodents. Cognitive Neuroscience of Memory Consolidation, 75-85.

AJ Park, R Havekes, X Fu, R Hansen, JC Tudor, L Peixoto, Z Li, YC Wu, SG Poplawski, JM Baraban, T Abel (2017) Learning induces the translin/trax RNase complex to express activin receptors for persistent memory. Life, 6.

H Schoch, AS Kreibich, SL Ferri, RS White, D Bohorquez, A Banerjee, RG Port, HC Dow, L Cordero, AA Pallathra, H Kim, H Li, WB Biker, S Hirano, RT Schultz, K Borgmann-Winter, CG Hahn, D Feldmeyer, GC Carlson, T Abel, ES Brodkin. (2017) Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene. Biological psychiatry 81 (3), 193-202.

V Luczak, KT Blackwell, T Abel, JA Girault, N Gervasi. (2017) Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during β-adrenergic receptor activation. Neurobiology of learning and memory 138, 10-20.

CC Angelakos, AJ Watson, WT O’Brien, KS Krainock, T Nickl‐Jockschat, T Abel. (2017) Hyperactivity and male‐specific sleep deficits in the 16p11. 2 deletion mouse model of autism. Autism Research 10 (4), 572-584.

A Günther, V Luczak, T Abel, A Baumann. (2017) Caspase-3 and GFAP as early markers for apoptosis and astrogliosis in shRNA-induced hippocampal cytotoxicity. Journal of Experimental Biology 220 (8), 1400-1404.

MS Bridi, JD Hawk, S Chatterjee, S Safe, T Abel. Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner. Neuropsychopharmacology 42 (6), 1243.

AV Ciernia, EA Kramár, DP Matheos, R Havekes, TJ Hemstedt, CN Magnan, K Sakata, A Tran, S Azzawi, A Lopez, R Dang, W Wang, B Trieu, J Tong, RM Barrett, RJ Post, P Baldi, T Abel, G Lynch, MA Wood. (2017) Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling. Learning & Memory 24 (5), 199-209.

R Havekes, T Abel. (2017) The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function. Current opinion in neurobiology 44, 13-19.

P Mews, G Donahue, AM Drake, V Luczak, T Abel, SL Berger. (2017) Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature 546 (7658), 381.

J Jȩdrzejewska-Szmek, V Luczak, T Abel, KT Blackwell. (2017) β-adrenergic signaling broadly contributes to LTP induction. PLoS computational biology 13 (7), e1005657.

J Li, W Zhang, H Yang, DP Howrigan, B Wilkinson, T Souaiaia, OV Evgrafov, G Genovese, VA Clementel, JC Tudor, T Abel, JA Knowles, BM Neale, K Wang, F Sun, MP Coba. (2017) Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nature neuroscience 20 (8), 1150.

Charles M. Brenner

Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C. (2016) Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk. J Nutr. 146(5):957-63.

J.L. Wilsbacher, M. Cheng, D. Cheng, S.A.J. Trammell, Y. Shi, J. Guo, S.L. Koeniger, P.J. Kovar, Y. He, S. Jagadeeswaran, H.R. Heyman, B.K. Sorensen, R.F. Clark, T.M. Hansen, K.L. Longenecker, D. Raich,  A.V. Korepanova, D.L. Towne, V.C. Abraham, H. Tang, S.M. McLoughlin, M.L. Curtin, M.R. Michaelides, D. Maag, F.G. Buchanan, W. Gao, S.H. Rosenberg, C. Brenner & C. Tse. (2017) Discovery and Characterization of Novel, Orally Bioavailable Non-substrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics, v. 16, pp. 1236-1245.

M.V. Hamity, S.R. White, R.Y. Walder, M.S. Schmidt, C. Brenner & D.L. Hammond. (2017) Nicotinamide Riboside, a Form of Vitamin B3 and NAD+ Precursor, Relieves the Nociceptive and Aversive Dimensions of Paclitaxel-induced Peripheral Neuropathy in Female Rats. Pain, v. 158, pp. 962–972.

Fletcher, J. Ratajczak, C.L. Doig, L.A. Oakey, R.Callingham, G. da Silva Xavier, A. Garten, Y.S. Elhassan, P. Redpath, M.E. Migaud, A. Philp, C. Brenner, C. Canto & G.G. Lavery. (2017) Nicotinamide Riboside Kinases Display Redundancy in Mediating Nicotinamide Mononucleotide and Nicotinamide Riboside Metabolism in Skeletal Muscle Cells. Molecular Metabolism, v. 6.

Vaur, B. Brugg, M. Mericskay, Z. Li, M.S. Schmidt, D. Vivien, C. Orset, E. Jacotot, C. Brenner & E. Duplus. (2017) Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration. FASEB Journal.

S.Thakur & C. Brenner. (2017) KRAS-driven miR-29b Expression is Required for Tumor Suppressor Gene Silencing. Oncotarget, v.8(43), pp. 74755-74766.

Sato, G. Solanas, F.O. Peixoto, L. Bee, A. Symeonidi, M.S. Schmidt, C. Brenner, S. Masri, S.A. Benitah & P. Sassone-Corsi. (2017) Circadian Reprogramming Identifies Metabolic Pathways of Aging. Cell, v. 170(4), pp. 664-677.

John M. Dagle

Sampath V, Bhandari V, Berger J, Merchant D, Zhang L, Ladd M, Menden H, Garland J, Ambalavanan N, Mulrooney N, Quasney M, Dagle J, Lavoie PM, Simpson P, Dahmer M. (2017) A Functional ATG16L1 (T300A) Variant is Associated with Necrotizing Enterocolitis in Premature Infants. Pediatr Res, 81(4):582-588.

Boghossian NS, Do BT, Bell EF, Dagle JM, Brumbaugh JE, Stoll BJ, Vohr BR, Das A, Shankaran S, Sanchez PJ, Wyckoff MH, Bethany Ball M, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (2017) Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infantsEarly Human Development. 113:10-17.

Kaluarachchi DC, Smith CJ, Klein JM, Murray JC, Dagle JM, Ryckman KK. (2017) Polymorphisms in urea cycle enzyme genes are  associated with persistent pulmonary hypertension of the newborn. Pediatr Res. 83(1-1):142-147.

Smith CJ, Ryckman KK, Bahr TM, Dagle JM. Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus. Pediatr Res. 82(5):776-780.

Morrow LA, Wagner BD, Ingram DA, Poindexter BB, Schibler K, Cotten CM, Dagle J, Sontag MK, Mourani PM, Abman SH. Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm InfantsAm J Respir Crit Care Med. 196(3):364-374.

Noonan M, Turek JW, Dagle J, McElroy SJ. (2017) Intraoperative High-Frequency Jet Ventilation Is Equivalent to Conventional Ventilation During Patent Ductus Arteriosus Ligation. World J Pediatr Congenit Heart Surg. 8(5):570-574.

Brandon Davies

Cushing EM, Chi X, Sylvers KL, Shetty SK, Potthoff MJ, Davies BSJ. (2017) Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. Mol Metab. 6(8):809–818.

Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing, EM, Li W, Dou A, Zhang R, Davies BSJ. (2017) ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 6(10):1137-1149.

Kris DeMali

Bays JL, DeMali KA. It takes energy to resist force. Cell Cycle. 16(19):1733-1734.

Bays JL, Campbell HK, Heidema C, Sebbagh M, DeMali KA. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.Nat Cell Biol. 19(6):724-731.

Bays JL, DeMali KA. (2017) Vinculin in cell-cell and cell-matrix adhesions.Cell Mol Life Sci. 74(16):2999-3009.

Campbell HK, Maiers JL, DeMali KA. (2017) Interplay between tight junctions & adherens junctions. Exp Cell Res. 358(1):39-44.

Adrian H. Elcock

Andrews, CT, Campbell, BA, Elcock, AH. (2017) Direct comparison of amino acid and salt interactions with double-stranded and single-stranded DNA from explicit-solvent molecular dynamics simulations. J. Chem. Theory Comput. 13, 1794-1811.

Miller, MS, Lay, WK, Li, S, Hacker, WC, An, J, Ren, J, Elcock, AH. (2017) Reparameterization of protein force field nonbonded interactions guided by osmotic coefficient measurements from molecular dynamics simulations. J. Chem. Theory Comput. 13, 1812-1826.

Lay, WK, Miller, MS, Elcock, AH. (2017) Reparameterization of solute-solute interactions for amino acid-sugar systems using isopiestic osmotic pressure molecular dynamics simulations. J Chem. Theory Comput. 13, 1874-1882.

Hacker, WC, Li, S, Elcock, AH. (2017) Features of genomic organization in a nucleotide-resolution molecular model of the Escherichia coli chromosome. Nucleic Acids Res. 45, 7541-7554.

Ernesto J. Fuentes

Mignon D., Panel N., Chen X., Fuentes E.J. and Simonson T. (2017) Computational design of the Tiam1 PDZ domain and its ligand binding. J Chem Theory Comput. 13(5):2271-2289.

Xu Z., Gakhar L., Bain F.E., Spies M. and Fuentes E.J. (2017) Tiam1 auto-inhibition by the N-terminal PHn-CC-Ex domain. J Biol Chem. 292(43):17777-17793.

Panel N., Sun Y.J., Fuentes E.J.* and Simonson T*. (2017) A simple PB/LIE free energy function accurately pre-dicts the peptide binding specificity of the Tiam1 PDZ domain. Front Mol Biosci. 4:65.

Lokesh Gakhar

Vance NR, Gakhar L, Spies MA. (2017) Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach. Angew Chem Int Ed Engl. 56(46):14443-14447.

Xu Z, Gakhar L, Bain FE, Spies M, Fuentes EJ. (2017) The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain. J Biol Chem. 292(43):17777-17793.

Yadav RP, Gakhar L, Yu L, Artemyev NO. (2017) Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc Natl Acad Sci U S A. 114(32):E6536-E6545.

Pamela K. Geyer

Baxley, R.M., Bullard, J.D, Klein, M.W., Fell, A.G., Morales-Rosado, J.A., Duan, T. and Geyer, P.K. (2017) Deciphering the DNA code for the function of the Drosophila polydactyl zinc-finger protein Suppressor of Hairy-wing. Nucl. Acid Res., 45(8):4463-4478

Catherine A. Musselman

Gatchalian J, Wang X, Ikebe J, Cox KL, Tencer AH, Zhang Y, Burge NL, Di L, Gibson MD, Musselman CA, Poirier MG, Kono H, Hayes JJ, Kutateladze TG. (2017) Accessibility of the histone H3 tail in the nucleosome for binding of paired readers. Nat Commun. 8(1):1489.

Tencer AH, Cox KL, Di L, Bridgers JB, Lyu J, Wang X, Sims JK, Weaver TM, Allen HF, Zhang Y, Gatchalian J, Darcy MA, Gibson MD, Ikebe J, Li W, Wade PA, Hayes JJ, Strahl BD, Kono H, Poirier MG, Musselman CA, Kutateladze TG. (2017) Covalent Modifications of Histone H3K9 Promote Binding of CHD3. Cell Rep. 21(2):455-466.

Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, Gu BX, Crabtree GR, Musselman CA. (2017) DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes. Nat Commun. 8:16080.

Flenker KS, Burghardt EL, Dutta N, Burns WJ, Grover JM, Kenkel EJ, Weaver TM, Mills J, Kim H, Huang L, Owczarzy R, Musselman CA, Behlke MA, Ford B, McNamara JO 2nd. (2017) Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity.  Mol Ther. 25(6):1353-1362.

Andrew W. Norris

Sun X, Yi Y, Xie W, Liang B, Winter MC, He N, Liu X, Luo M, Yang Y, Ode KL, Uc A, Norris AW, Engelhardt JF.  (2017) CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived FactorsEndocrinology. 158(10):3325-3338.

Coryell WH, Langbehn DR, Norris AW, Yao JR, Dindo LN, Calarge CA. (2017) Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence. Psychiatry Res. 256:305-311.

Bryce V. Plapp

K Kim and BV Plapp. (2017) Inversion of Substrate Stereoselectivity of Horse Liver Alcohol Dehydrogenase by Substitutions of Ser-48 and Phe-93. Chem. Biol. Interact. 276,77-87.

BV Plapp, BR Savarimuthu, DJ Ferraro, JK Rubach, EN Brown, and S Ramaswamy. (2017) Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis. Biochemistry. 56, 3632-3646.

David H. Price

Bosque, A., Nilson, K.A., Macedo, A.B., Spivak, A.M., Archin, N., Van Wagoner, R.M., Martins, L.J., Novis, C.L., Szaniawski, M.A., Ireland, C.M., Margolis, D.M, Price, D.H., Planelles, V. (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Reports, 18:1324-1334.

Brogie, J.E and Price D.H. (2017) Reconstitution of a functional 7SK snRNP. Nucleic Acids Res. 45(11):6864-6880.

Nilson, K.A., Lawson, C.K., Mullen, N.J., Ball, C.B., Spector, B.M., Meier, J.L., Price, D.H. (2017) Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome. Nucleic Acids Res. 45(19):11088-11105.

Mullen, NJ and Price DH. (2017) Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function. PLoS ONE, 12(10):e0186423.

Miles Pufall

Rollins DA, Kharlyngdoh JB, Coppo M, Tharmalingam B, Mimouna S, Guo Z, Sacta MA, Pufall MA, Fisher RP, Hu X, Chinenov Y, Rogatsky I. (2017) Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat Commun. 8(1):1739.

Pufall MA. (2017) Defining Native Enhancer Function. Cell Syst. 5(4):310-312.

Michaelson JJ, Shin MK, Koh JY, Brueggeman L, Zhang A, Katzman A, McDaniel L, Fang M, Pufall M, Pieper AA. (2017) Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes. Biol Psychiatry. 82(3):213-223.

Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. (2017) Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.  Blood. 129(22):3000-3008.

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. (2017) Metabolic gatekeeper function of B-lymphoid transcription factors.  Nature. 542(7642):479-483.

Peter A. Rubenstein

Niederhoffer EC, Cline SD, Osheroff N, Simmons JM, Diekman AB, Franklin DS, Abali EE, Bateman RC Jr, Fontes JD, Lindsley JE, Pearson D, Rubenstein PA, Slaughter CA, Bernstein JA, Hyland KM, Park VM, Sobering AK, Weiler TA, Dasgupta S. (2017) Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6thInternational Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017. Med Sci Educ. 27(4):855-859.

Michael J. Schnieders

Lansdon LA, Bernabe HV, Nidey N, Standley J, Schnieders MJ, Murray JC. (2017) The Use of Variant Maps to Explore Domain-Specific Mutations of FGFR1. J Dent Res. 96(11):1339-1345.

Simpson A, Avdic A, Roos BR, DeLuca A, Miller K, Schnieders MJ, Scheetz TE, Alward WL, Fingert JH. (2017) LADD syndrome with glaucoma is caused by a novel gene.  Mol Vis. 23:179-184.

Madeline Shea

*Hovey, L., *Fowler, C.A., Mahling, R., Lin, Z., Miller, M.S. Marx, D.C., Yoder, J.B., Kim, E.H.,Tefft, K.M., Waite, B.C., Feldkamp, M.D., Yu, L., Shea, M.A. (2017) Calcium Triggers Reversal of Calmodulin on Nested Anti-Parallel Sties in the IQ Motif of the Neuronal Voltage- Dependent Sodium Channel NaV1.2 . Biophysical Chemistry, 224:1-19.

Fowler, C.A., Núñez Hernandez, M., O’Donnell, S.E., Yu, L., and Shea, M.A. (2017) Backbone and Side-Chain Resonance Assignments of (Ca2+)4-Calmodulin Bound to Beta Calcineurin A CaMBD Peptide. Biomolecular NMR Assignments, 11:275–28

Mahling, R., Kilpatrick, A. M., and Shea, M.A. Backbone resonance assignments of complexes of human voltage-dependent sodium channel NaV1.2 IQ motif peptide bound to apo calmodulin and to the C-domain fragment of apo calmodulin. Biomolecular NMR Assignments, 11:297–303.

M. Ashley Spies

Vance, N.R, Gakhar, L., and Spies, M.A. (2017) Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery ApproachAngew Chem Int Ed. Eng. 56(46):14443-14447.

Hengel, S.R., Spies, M.A.*, and Spies, M.* (2017) Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem. Bio. 24(9):1101-1119.

Maria Spies

Hengel, S.R., Spies, M.A.*, and Spies, M.* (2017) Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem. Bio. 24(9):1101-1119.

Caldwell CC, Spies M. (2017) Helicase SPRNTing through the nanopore. Proc Natl Acad Sci U S A. 114(45):11809-11811.

Xu Z., Gakhar L., Bain F.E., Spies M. and Fuentes E.J. (2017) Tiam1 auto-inhibition by the N-terminal PHn-CC-Ex domain. J Biol Chem. 292(43):17777-17793.

Spies M, Smith BO. (2017) Protein-nucleic acids interactions: new ways of connecting structure, dynamics and function. Biophys Rev. 9(4):289-291.

Spies M. (2017) A time for promiscuity in a eukaryotic recombinase. J Biol Chem. 292(26):11136-11137.

Nancy C. Stellwagen

Stellwagen NC. (2017) Electrophoretic Mobilities of the Charge Variants of DNA and Other Polyelectrolytes: Similarities, Differences, and Comparison with Theory. J Phys Chem B. 121(9):2015-2026.

Eric B. Taylor

Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB. (2017) The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab. 6(11):1468-1479.

Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN. (2017) The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 102(8):985-999.

DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT. (2017) ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Rep. 19(9):1794-1806.

Taylor EB. (2017) Functional Properties of the Mitochondrial Carrier System. Trends Cell Biol. 27(9):633-644.

M. Todd Washington

Zhoa, L. and Washington, M. T. (2017) Translesion synthesis: Insights into the selection and switching of DNA polymerases. Genes, 8(1), e24.

Liu, J., Ede, C., Wright, W. D., Gore, S. K., Jenkins, S. S., Freudenthal, B. D., Washington, M. T., Veaute, X., and Heyer, W. D. (2017) Srs2 promotes synthesis-dependent strand annealing by disruptiong DNA polymerase delta-extending D-loops. eLife 6, e22195.

Powers, K. T. and Washington, M. T. (2017) Analyzing the catalytic activities and interactions of eukaryotic translesion synthesis. Methods Enzymol. 592, 329-356.

Ronald J. Weigel

De Andrade JP, Lorenzen AW, Wu VT, Bogachek MV, Park JM, Gu VW, Sevenich CM, Cassady VC, Beck AC, Kulak MV, Robinson RA, Lal G, Weigel RJ. (2017) Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer. Oncotarget. 8(70):114801-114815.

Wu VT, Lorenzen AW, Beck AC, Reid VJ, Sugg SL, Howe JR, Pollard JH, Lal G, Weigel RJ. (2017) Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease. Surgery. 161(1):147-155.

Gómez-Contreras P, Ramiro-Díaz JM, Sierra A, Stipp C, Domann FE, Weigel RJ, Lal G. (2017) Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases. Clin Exp Metastasis. 34(1):37-49.

Thomas A, Weigel RJ, Lynch CF, Spanheimer PM, Breitbach EK, Schroeder MC. (2017) Incidence, characteristics, and management of recently diagnosed, microscopically invasive breast cancer by receptor status: Iowa SEER 2000 to 2013. Am J Surg. 214(2):323-328.

Marc S. Wold

Zhang, H., Gan, H., Wang, Z. Lee, J-H., Zhou, H. Ordog, T., Wold, M.S., Ljungman, M., Zhang, Z. (2017) RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells. Molecular Cell 65, 272-282.

Meng Wu

Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller M, Tian J, Zhu J, Xu J, Wen M, Er-Bu A, Wang J, Xiao Y, Wu M, McManus OB, Li M, Wu J, Luo HR, Cao Z, Shen B, Wang H, Zhu MX, Hong X. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem. 60(11):4680-4692.

Liping Yu

Fowler, C.A., Núñez Hernandez, M., O’Donnell, S.E., Yu, L., and Shea, M.A. (2017) Backbone and Side-Chain Resonance Assignments of (Ca2+)4-Calmodulin Bound to Beta Calcineurin A CaMBD Peptide. Biomolecular NMR Assignments, 11:275–280.

Yadav RP, Gakhar L, Yu L, Artemyev NO. (2017) Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc Natl Acad Sci U S A. 114(32):E6536-E6545.

B. Fink, F. Bai, L. Yu, and W. Sivitz. (2017) Regulation of ATP production: dependences on calcium concentration and respiratory state. American Journal of Physiology – Cell Physiology, 313, C146-C153. DOI: 10.1152/ajpcell.00086.2017.

L. Yu, R.P. Yadav, and N.O. Artemyev. (2017) NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand. Biomol. NMR Assign., 11, 111-115. DOI: 10.1007/s12104-017-9730-2.

*Hovey, L., *Fowler, C.A., Mahling, R., Lin, Z., Miller, M.S. Marx, D.C., Yoder, J.B., Kim, E.H.,Tefft, K.M., Waite, B.C., Feldkamp, M.D., Yu, L., Shea, M.A. (2017) Calcium Triggers Reversal of Calmodulin on Nested Anti-Parallel Sties in the IQ Motif of the Neuronal Voltage-Dependent Sodium Channel NaV1.2 . Biophysical Chemistry, 224:1-19.

Dr. Shea’s Biophysical Society Blog “Making the Most of the Annual Meeting: Tips for First-Timers”

February 15th, 2018 by Maren Rogers

Dr. Madeline Shea will be presented with the Emily M. Gray Award in Education at the 62nd Annual Meeting of the Biophysical Society in San Francisco on February 19. In advance of the meeting, Dr. Shea published a blog piece to help first-time attendees at the meeting. Read her advice here:

Congrats Fall 2017 Biochemistry PhD Graduates

January 16th, 2018 by Briana Horwath

Shuxiang Li, a Biochemistry PhD student mentored by Dr. Adrian Elcock, received a PhD on December 15,2017 entitled, “Computer simulations exploring conformational preferences of short peptides and developing a bacterial chromosome model”. Shuxiang has accepted a postdoctoral position with Dr. Wilma Olson’s Laboratory at Rutgers University.


Liyang Zhang, a Biochemistry PhD student mentored by Dr. Miles Pufall, received a PhD on December 15, 2017 entitled, “Defining the DNA Binding Energetics of the Glucocorticoid Receptor”. Liyang has accepted a position with Integrated DNA Technologies.

Congrats Shuxiang and Liyang!

Dr. Weeks receives 2017 CCOM Faculty Service Award

December 22nd, 2017 by Maren Rogers

Congratulations to Dr. Daniel Weeks, who was awarded the 2017 Faculty Service Award from the Carver College of Medicine (CCOM). Dr.  Weeks is an internationally known nuclei acid biochemistry and developmental biologist who has had a productive research career and won many teaching awards. Dr. Weeks has dedicated three decades of service to CCOM. His service activities have been diverse and of the highest impact. Thousands of students have benefited from his guidance and educational programming, establishing a strong foundation for their future careers. Of special note is Dr. Weeks’ strong dedication to curriculum development. He served on the Medical Education and Curriculum Committee from 1989-2003 and on the College of Medicine Curriculum Review/Steering Committee from 2014 – present. CCOM’s recent re-accreditation and the success of the New Horizons Curriculum are due in part to his tireless efforts.



Dr. Fuentes receives 2017 CCOM Collegiate Teaching Award

December 22nd, 2017 by Maren Rogers

Congratulations to Dr. Ernesto Fuentes for being chosen to receive a Carver College of Medicine (CCOM) Collegiate Teaching Award for 2017. Dr. Fuentes’ didactic teaching has included an unusually wide range of topics such as protein structure analysis, enzyme kinetics and molecular biology. He has taught a broad range of students in undergraduate laboratory courses (Biochem. 99:140) and large lecture courses (BIOC:3110) and graduate students in small group discussions (MCB 156:210) and larger didactic (BIOC:5242). In addition, he has organized workshops centered on NMR methodology for a wide range of individuals including faculty members. Whether it is in a classroom, conference room, or at a laboratory bench, his primary goal is to make sure that students understand concepts of biochemistry and their research projects.

Among current Biochemistry primary faculty, Dr. Fuentes joins Drs. Peter Rubenstein, Adrian Elcock, Lori Wallrath, Dan Weeks, Todd Washington, Kris DeMali, Pamela Geyer, and Marc Wold as recipients of the CCOM Collegiate Teaching Award.

2017 Biochemistry Newsletter now available

November 16th, 2017 by Maren Rogers

The 2017 Biochemistry @ Iowa newsletter is hot off the presses and available for download. Alumni and friends should receive a hard copy in the mail this week. If you would like to be added to our mailing list, please send your contact information to While you are at it, feel free to send us your news and updates! Previous newsletters are also available online.

Miles Pufall received Donald D. Dorfman Award

October 31st, 2017 by Maren Rogers

Dr. Miles Pufall received the 2017 Donald D. Dorfman Award of $10,000 for his paper entitled “Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia,” which was published in the June 2017 issue of Blood. The Dorfman Award is given annually to the best research papers in leukemia and lymphoma research among members of the Holden Comprehensive Cancer Center. Congratulations, Dr. Pufall!

Ryan Sheldon receives F32 award

September 18th, 2017 by Maren Rogers

Ryan Sheldon, a Postdoc in the Taylor laboratory, received an F32 Postdoctoral Fellowship awarded by the National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Sheldon’s project entitled “Regulation of Hepatic Lipogenesis by a Mitochondrial Pyruvate Carrier-Citrate Carrier Axis,” addresses the major public health problem of hyperlipidemia during Type 2 Diabetes.

Excess lipid production in the liver during type 2 diabetes leads to elevated lipids in the liver and circulation, which in turn drives many diabetes associated complications. The liver can make lipids from glucose. To do this, the glucose metabolite pyruvate is imported into mitochondria, converted to citrate, and exported to the cytosol, where is it channeled into pathways for making cholesterol and fatty acids. This research project seeks to understand how the mitochondrial pyruvate carrier and mitochondrial citrate carrier work together to influence liver lipid synthesis, accumulation, and release. Success may reveal opportunities for decreasing liver and circulating lipid content, thereby improving health outcomes in type 2 diabetes.

Congratulations, Ryan!

Elizabeth Boehm receives 2017 Subramanian Thesis Award

August 31st, 2017 by Maren Rogers

Elizabeth Boehm, who completed her PhD with Dr. M. Todd Washington, has been awarded the 2017 Subramanian Award for best PhD thesis in the Department of Biochemistry. Dr. Boehm’s thesis was entitled “The regulation of translesion synthesis through binding and activation of polymerases by PCNA.” Elizabeth received her PhD in June 2016 and is currently a postdoctoral fellow in the lab of Johannes Walter at Harvard Medical School.

Elizabeth is the 22nd winner of the Subramanian Award, which is made possible by a gift from Dr. Alap Subramanian, a 1964 PhD from the department, who parlayed his training with the late George Kalnitsky, (and with Irving Klotz at Northwestern and both Bernard Davis and Herman Kalckar at Harvard Medical School), into a highly successful career at the Max-Planck-Institut. Our deepest thanks to Dr. Subramanian and our heartiest congratulations to Dr. Boehm.

Please visit our website for a complete list of previous winners of the Subramanian Award.

Highlights of the 8th Annual Biochemistry Retreat

August 31st, 2017 by Briana Horwath

The Department of Biochemistry held their 8th Annual Retreat on August, 26, 2017, in the Pomerantz Center on the University of Iowa Campus. The retreat featured talks by Brittany Ripley (Graduate Student-Washington Lab), Pamela Geyer (Professor), Adam Rauckhorst (Postdoc.-Taylor Lab), and Maria Spies (Professor) and 32 poster presentations.

It was exciting to learn about all the science happening in the Department! Congratulations to the winners of the various contests listed below.

Graduate Student/Postdoc Poster Competition
There was a three way tie for 1st place.
Emily Malcolm Cushing (Davies Lab) “GPIHBP1-independent mechanisms of triglyceride clearance”
Lalita Oonthonpan (Taylor Lab) “A conserved role for the MPC1 C-terminus in MPC complex assembly and function”
Arpit Sharma (Taylor Lab) “Loss of skeletal muscle Mpc1 in mice stimulates fatty acid oxidation, leanness, and nitrogen retention”

Undergraduate/Others Poster Competition
Myles Young (Taylor Lab) “Nutritional-metabolic regulation of mitochondrial morphology”

Art Show Competition
Tingting Duan (Geyer Lab) “The Beauty of Drosophila”