Link: University of Iowa

Maria Spies lab publishes in PNAS

Dr. Maria Spies laboratory recently published an Proceedings of National Academy of Sciences article entitled “Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics.” In this article the Spies laboratory addressed the regulation of the homologous genetic recombination, an enigmatic cellular mechanism responsible for the stability of our genomes and accurate repair of the most deleterious DNA damage. They combined the tools of biochemistry, chemical biology and single-molecule biophysics to determine the mechanism by which c-ABL kinase (and its oncogenic counterpart BCR-ABL) enhances the activity of human RAD51 recombinase, which catalyzes the central step in homologous recombination. Recent PhD, Shyamal Subramanyam, was first author of this work, which was a cornerstone of his dissertation.

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