Link: University of Iowa

Maria Spies lab publishes in eLife Sciences

Dr. Maria Spies laboratory in collaboration with Dr. Ashley Spies laboratory recently published an eLife Sciences article entitled “Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells.” In this study, Hengel et al. developed a high throughput biophysical method to search through a large collection of small molecules to find those that prevent RAD52 from binding to DNA and then used the information about how the small molecules bind to RAD52 to preform further computational screening. This identified a natural compound that competes with single-stranded DNA to bind to RAD52. The activity of this molecule was then validated using biophysical methods. The methods used by Hengel et al. provide the foundation for further searches for new anticancer drugs. Future studies that employ the small molecule drugs identified so far will also help to determine exactly how RAD52 works in human cells and how it helps cancer cells to survive.

This article was Ms. Sarah Hengel’s first, first author paper. Congratulations, Sarah!

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