Link: University of Iowa

Fuentes group featured on the March 5 cover of Structure

Dr. Ernie Fuentes was senior author on a study on the Tiam1 PDZ domain bound with (phos) syndecan1 (SDC1) ligands. The x-ray crystallographic studies show how the Tiam1 PDZ domain preferentially interacts with a subset of SDC proteins, while NMR studies indicate the dynamic decoupling stimulated by SDC1 phosphorylation. The findings reveal a phosphorylation-based regulation mechanism on the selection of SDC ineratome. The paper was published in the March 5 issue of Structure, along with a cover image that illustrates the syndecan intractome and how a PDZ domain selects its partner protein. The paper is also a recommended article on Faculty of 1000 Prime, and is co-authored by current and former members of the Fuentes lab including current graduate students Xu Liu (first author) and Zhen Xu, former graduate student Tyson Shepherd, and Ann Murray.

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