Link: University of Iowa

Dr. Andrew Norris receives new NIH R01

Dr. Andrew Norris, Associate Professor of Pediatrics and Biochemistry, received a new NIH R01 in collaboration with Dr. John Engelhart, Professor and Chair of Anatomy & Cell Biology, entitled “Splanchno-Hormonal Mechanisms of Cystic Fibrosis Related Diabetes.” For unclear reasons most people who have cystic fibrosis will develop diabetes by middle age, placing them at much higher risk of lung failure and death. Drs. Norris and Engelhardt’s data suggest that low levels of a hormone called pancreatic polypeptide (PP) raises diabetes risk in patients with cystic fibrosis. This study aims to understand why PP is low in cystic fibrosis and to apply this knowledge to develop new therapies for diabetes in cystic fibrosis patients.  PP-based therapies may have potential to treat other types of diabetes as well.

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