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Archive for the ‘Nicholas Mullen’ Category

13th Annual Gene F. Lata Undergraduate Research Symposium

Friday, May 5th, 2017

Eight students presented at this year’s Undergraduate Honors Program. This year marks the thirteenth year for the Gene F. Lata Undergraduate Research Symposium. Please join Professor Marc Wold, Director of Undergraduate Studies and Honors Advisor, in congratulating these 2017 graduates and their research mentors for a job well done.

(left to right): Emily Britt, Sarah Gardner, Zachary Wehrspan, Maria Núñez Hernandez, Maureen O’Connor, Sarah Van Dorin, Nicholas McCarty, Nicholas Mullen
  • Emily C. Britt
    Mentor: Brandon Davies
    Investigating the Interactions Between ANGPTL3, ANGPTL8, and Lipoprotein Lipase
  • Sarah H. Gardner
    Mentor: Sheila Baker
    Post-Synaptic Development of the First Visual Synapse
  • Maria Núñez Hernandez
    Mentor: Madeline Shea
    Calcium-Dependent Regulation of Calcineurin Activity
  • Nicholas S. McCarty
    Mentor: E. Dale Abel
    Exploring Mechanisms by which the Insulin Responsive Glucose Transporter GLUT4 is Regulated in High-Fat Fed Hearts
  • Nicholas J. Mullen
    Mentor: David Price
    Oxidative Stress Reveals Mechanistic Insight into Human 5’ mRNA Capping
  • Maureen O’Connor
    Mentor: Lori Wallrath
    Lamin localization and genome integrity in rare types of muscular dystrophy
  • Sarah Van Dorin
    Mentor: Ronald Weigel
    Role of TFAP2A in Transcriptional Regulation of Melanoma
  • Zachary Wehrspan
    Mentor: Ronald Weigel
    TFAP2C orchestrates pH regulation in breast tumors, and its loss leads to EMT, facilitating the Warburg Effect

The symposium also included the presentation of two undergraduate awards, made possible by a gift from Alap Subramanian. The H.G. Wittmann Scholar Award was presented to Nicholas J. Mullen (Price lab) and the H.G. Khorana Scholar Award was presented to Emily Britt (Davies lab), recognizing their exceptional understanding of biochemistry and its value to society.

Congratulations to everyone named above and all of our 2017 graduates!

Price lab featured on the August cover of Molecular Cell

Thursday, August 20th, 2015

MOLCEL_59_4.c1.inddDavid Price‘s lab was featured on the August 20 cover of Molecular Cell. The article entitled “THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing,”shows how a Cdk7 inhibitor, THZ1, dramatically impacts CTD phosphorylation, co-transcriptional capping, pausing, and P-TEFb-dependent productive elongation by disrupting an ordered exchange of factors after initiation. These results provide mechanistic insights into the anti-proliferative and super-enhancer-selective effects of THZ1 seen by others. Kyle Nilson, (Molecular and Cellular Biology Graduate Student in the Price Lab) was first author of this work. John Brogie (Biochemistry Graduate Student), Michael Turek (Biochemistry Undergraduate Major), and Jiannan Guo (Former Biochemistry Postdoc, Price Lab) also contributed to this work. The cover design by Kyle Nilson features and experiment “performed” by Nicholas Mullen (Biochemistry Undergraduate Major).

The article is also featured in a preview by Drs. Frédéric Coin and Jean-Marc Egly entitiled “Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor.”

Congratulations Price Lab!!