Link: University of Iowa

Archive for the ‘Bret Freudenthal’ Category

Bret Freudenthal wins the Subramanian Thesis Award

Monday, August 30th, 2010

Bret Freudenthal, who recently completed his PhD with Todd Washington, has been named the winner of the 2010 Subramanian Award for best PhD thesis in the Department of Biochemistry. Dr. Freudenthal was an American Heart Association-funded graduate student who focused on the structural biology and enzymology of wild-type and mutant proliferating cell nuclear antigen (PCNA) in promoting translesion DNA synthesis. His first author publications include a Biochemistry report, an Acta Cryst D contribution, and a Nature Struct Mol Biol paper, which was highlighted in Nature Chem Biol.

Bret is no stranger to Biochemistry awards, having been given an inaugural Gehring Award last fall. He is bound for the National Institutes of Environmental Health Sciences to work with Dr. Samuel Wilson.

Bret is the 17th winner of the Subramanian Award, which is made possible by a gift from Dr. Alap Subramanian, a 1964 PhD from the department, who parlayed his training with the late George Kalnitzky into a highly successful career at the Max-Planck-Institut. Our deepest thanks to Dr. Subramanian and our heartiest congratulations to Dr. Freudenthal.

Dr. Bret Freudenthal

Wednesday, April 21st, 2010

Congratulations are due to our newest PhD, Bret Freudenthal. A member of Todd Washington’s research group, Dr. Freudenthal defended his thesis on “Studies of proliferating cell nuclear antigen and its role in translesion synthesis.” He plans to conduct post-doctoral research on DNA metabolism, specifically focusing on DNA repair or recombination. Watch this space for an announcement of post-doctoral plans.

Structure of Monoubiquitylated PCNA

Tuesday, March 23rd, 2010

The proliferating cell nuclear antigen (PCNA) is a trimeric, ring-shaped protein that slides along DNA to promote replication. When DNA is damaged, a replicative polymerase is replaced by a translesion polymerase in a process that involves addition of a single ubiquitin modification to each PCNA monomer. How this modification changes the appearance and function of PCNA was not understood until Todd Washington’s laboratory developed an ingenious trick. (more…)

Dr. Lois Bigger Gehring Awardees

Tuesday, September 22nd, 2009

Lois Bigger Gehring, a great friend of the Department of Biochemistry, has created an endowment for the Department to support graduate students.   (more…)