Link: University of Iowa

Archive for the ‘Pamela Geyer’ Category

2017 Faculty Publications

Thursday, March 1st, 2018

The Department’s 2017 publications are now in print and mostly available online.

E. Dale Abel

Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KM, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. (2017) OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO Journal. 36(14):2126-2145.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. (2017) Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nature communications. 8:14095.

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. (2017) SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nature Cell Biology. 19(5):504-517.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. (2017) DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metabolism. 25(5):1135-1146.e7.

Fidler TP, Middleton E, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. (2017) Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation, Arteriosclerosis, Thrombosis, and Vascular Biology. Arterioscler Thromb Vasc Biol. 37(9):1628-1639.

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED. (2017) Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Reports. 20(4):881-894.

Wende AR, Kim J, Holland W, Wayment BE, O’Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. (2017) Glucose transporter 4 (GLUT4) deficient hearts develop maladaptive hypertrophy in response to physiologic or pathologic stresses., American journal of physiology. Heart and circulatory physiology.

Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. (2017) Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free radical biology & medicine. 113:16-25.

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. (2017) Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission. Circulation research.

Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S. (2018) Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. Journal of molecular and cellular cardiology. 113:39-50.

Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. (2017) Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI insight. 2(24).

Ted Abel

G Kronberg, M Bridi, T Abel, M Bikson, LC Parra. (2017)  Direct current stimulation modulates LTP and LTD: activity dependence and dendritic effects. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 10:1, 51-85.

G Kronberg, M Bridi, T Abel, LC Parra. (2017) Electric Fields Boost LTP in Vitro. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 10:1, e14-e15.

JC Kreutzmann, JC Tudor, CC Angelakos, T Abel. (2017) The Impact of Sleep Deprivation on Molecular Mechanisms of Memory Consolidation in Rodents. Cognitive Neuroscience of Memory Consolidation, 75-85.

AJ Park, R Havekes, X Fu, R Hansen, JC Tudor, L Peixoto, Z Li, YC Wu, SG Poplawski, JM Baraban, T Abel (2017) Learning induces the translin/trax RNase complex to express activin receptors for persistent memory. Life, 6.

H Schoch, AS Kreibich, SL Ferri, RS White, D Bohorquez, A Banerjee, RG Port, HC Dow, L Cordero, AA Pallathra, H Kim, H Li, WB Biker, S Hirano, RT Schultz, K Borgmann-Winter, CG Hahn, D Feldmeyer, GC Carlson, T Abel, ES Brodkin. (2017) Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene. Biological psychiatry 81 (3), 193-202.

V Luczak, KT Blackwell, T Abel, JA Girault, N Gervasi. (2017) Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during β-adrenergic receptor activation. Neurobiology of learning and memory 138, 10-20.

CC Angelakos, AJ Watson, WT O’Brien, KS Krainock, T Nickl‐Jockschat, T Abel. (2017) Hyperactivity and male‐specific sleep deficits in the 16p11. 2 deletion mouse model of autism. Autism Research 10 (4), 572-584.

A Günther, V Luczak, T Abel, A Baumann. (2017) Caspase-3 and GFAP as early markers for apoptosis and astrogliosis in shRNA-induced hippocampal cytotoxicity. Journal of Experimental Biology 220 (8), 1400-1404.

MS Bridi, JD Hawk, S Chatterjee, S Safe, T Abel. Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner. Neuropsychopharmacology 42 (6), 1243.

AV Ciernia, EA Kramár, DP Matheos, R Havekes, TJ Hemstedt, CN Magnan, K Sakata, A Tran, S Azzawi, A Lopez, R Dang, W Wang, B Trieu, J Tong, RM Barrett, RJ Post, P Baldi, T Abel, G Lynch, MA Wood. (2017) Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling. Learning & Memory 24 (5), 199-209.

R Havekes, T Abel. (2017) The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function. Current opinion in neurobiology 44, 13-19.

P Mews, G Donahue, AM Drake, V Luczak, T Abel, SL Berger. (2017) Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature 546 (7658), 381.

J Jȩdrzejewska-Szmek, V Luczak, T Abel, KT Blackwell. (2017) β-adrenergic signaling broadly contributes to LTP induction. PLoS computational biology 13 (7), e1005657.

J Li, W Zhang, H Yang, DP Howrigan, B Wilkinson, T Souaiaia, OV Evgrafov, G Genovese, VA Clementel, JC Tudor, T Abel, JA Knowles, BM Neale, K Wang, F Sun, MP Coba. (2017) Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nature neuroscience 20 (8), 1150.

Charles M. Brenner

Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C. (2016) Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk. J Nutr. 146(5):957-63.

J.L. Wilsbacher, M. Cheng, D. Cheng, S.A.J. Trammell, Y. Shi, J. Guo, S.L. Koeniger, P.J. Kovar, Y. He, S. Jagadeeswaran, H.R. Heyman, B.K. Sorensen, R.F. Clark, T.M. Hansen, K.L. Longenecker, D. Raich,  A.V. Korepanova, D.L. Towne, V.C. Abraham, H. Tang, S.M. McLoughlin, M.L. Curtin, M.R. Michaelides, D. Maag, F.G. Buchanan, W. Gao, S.H. Rosenberg, C. Brenner & C. Tse. (2017) Discovery and Characterization of Novel, Orally Bioavailable Non-substrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics, v. 16, pp. 1236-1245.

M.V. Hamity, S.R. White, R.Y. Walder, M.S. Schmidt, C. Brenner & D.L. Hammond. (2017) Nicotinamide Riboside, a Form of Vitamin B3 and NAD+ Precursor, Relieves the Nociceptive and Aversive Dimensions of Paclitaxel-induced Peripheral Neuropathy in Female Rats. Pain, v. 158, pp. 962–972.

Fletcher, J. Ratajczak, C.L. Doig, L.A. Oakey, R.Callingham, G. da Silva Xavier, A. Garten, Y.S. Elhassan, P. Redpath, M.E. Migaud, A. Philp, C. Brenner, C. Canto & G.G. Lavery. (2017) Nicotinamide Riboside Kinases Display Redundancy in Mediating Nicotinamide Mononucleotide and Nicotinamide Riboside Metabolism in Skeletal Muscle Cells. Molecular Metabolism, v. 6.

Vaur, B. Brugg, M. Mericskay, Z. Li, M.S. Schmidt, D. Vivien, C. Orset, E. Jacotot, C. Brenner & E. Duplus. (2017) Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration. FASEB Journal.

S.Thakur & C. Brenner. (2017) KRAS-driven miR-29b Expression is Required for Tumor Suppressor Gene Silencing. Oncotarget, v.8(43), pp. 74755-74766.

Sato, G. Solanas, F.O. Peixoto, L. Bee, A. Symeonidi, M.S. Schmidt, C. Brenner, S. Masri, S.A. Benitah & P. Sassone-Corsi. (2017) Circadian Reprogramming Identifies Metabolic Pathways of Aging. Cell, v. 170(4), pp. 664-677.

John M. Dagle

Sampath V, Bhandari V, Berger J, Merchant D, Zhang L, Ladd M, Menden H, Garland J, Ambalavanan N, Mulrooney N, Quasney M, Dagle J, Lavoie PM, Simpson P, Dahmer M. (2017) A Functional ATG16L1 (T300A) Variant is Associated with Necrotizing Enterocolitis in Premature Infants. Pediatr Res, 81(4):582-588.

Boghossian NS, Do BT, Bell EF, Dagle JM, Brumbaugh JE, Stoll BJ, Vohr BR, Das A, Shankaran S, Sanchez PJ, Wyckoff MH, Bethany Ball M, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (2017) Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infantsEarly Human Development. 113:10-17.

Kaluarachchi DC, Smith CJ, Klein JM, Murray JC, Dagle JM, Ryckman KK. (2017) Polymorphisms in urea cycle enzyme genes are  associated with persistent pulmonary hypertension of the newborn. Pediatr Res. 83(1-1):142-147.

Smith CJ, Ryckman KK, Bahr TM, Dagle JM. Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus. Pediatr Res. 82(5):776-780.

Morrow LA, Wagner BD, Ingram DA, Poindexter BB, Schibler K, Cotten CM, Dagle J, Sontag MK, Mourani PM, Abman SH. Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm InfantsAm J Respir Crit Care Med. 196(3):364-374.

Noonan M, Turek JW, Dagle J, McElroy SJ. (2017) Intraoperative High-Frequency Jet Ventilation Is Equivalent to Conventional Ventilation During Patent Ductus Arteriosus Ligation. World J Pediatr Congenit Heart Surg. 8(5):570-574.

Brandon Davies

Cushing EM, Chi X, Sylvers KL, Shetty SK, Potthoff MJ, Davies BSJ. (2017) Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. Mol Metab. 6(8):809–818.

Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing, EM, Li W, Dou A, Zhang R, Davies BSJ. (2017) ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 6(10):1137-1149.

Kris DeMali

Bays JL, DeMali KA. It takes energy to resist force. Cell Cycle. 16(19):1733-1734.

Bays JL, Campbell HK, Heidema C, Sebbagh M, DeMali KA. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.Nat Cell Biol. 19(6):724-731.

Bays JL, DeMali KA. (2017) Vinculin in cell-cell and cell-matrix adhesions.Cell Mol Life Sci. 74(16):2999-3009.

Campbell HK, Maiers JL, DeMali KA. (2017) Interplay between tight junctions & adherens junctions. Exp Cell Res. 358(1):39-44.

Adrian H. Elcock

Andrews, CT, Campbell, BA, Elcock, AH. (2017) Direct comparison of amino acid and salt interactions with double-stranded and single-stranded DNA from explicit-solvent molecular dynamics simulations. J. Chem. Theory Comput. 13, 1794-1811.

Miller, MS, Lay, WK, Li, S, Hacker, WC, An, J, Ren, J, Elcock, AH. (2017) Reparameterization of protein force field nonbonded interactions guided by osmotic coefficient measurements from molecular dynamics simulations. J. Chem. Theory Comput. 13, 1812-1826.

Lay, WK, Miller, MS, Elcock, AH. (2017) Reparameterization of solute-solute interactions for amino acid-sugar systems using isopiestic osmotic pressure molecular dynamics simulations. J Chem. Theory Comput. 13, 1874-1882.

Hacker, WC, Li, S, Elcock, AH. (2017) Features of genomic organization in a nucleotide-resolution molecular model of the Escherichia coli chromosome. Nucleic Acids Res. 45, 7541-7554.

Ernesto J. Fuentes

Mignon D., Panel N., Chen X., Fuentes E.J. and Simonson T. (2017) Computational design of the Tiam1 PDZ domain and its ligand binding. J Chem Theory Comput. 13(5):2271-2289.

Xu Z., Gakhar L., Bain F.E., Spies M. and Fuentes E.J. (2017) Tiam1 auto-inhibition by the N-terminal PHn-CC-Ex domain. J Biol Chem. 292(43):17777-17793.

Panel N., Sun Y.J., Fuentes E.J.* and Simonson T*. (2017) A simple PB/LIE free energy function accurately pre-dicts the peptide binding specificity of the Tiam1 PDZ domain. Front Mol Biosci. 4:65.

Lokesh Gakhar

Vance NR, Gakhar L, Spies MA. (2017) Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach. Angew Chem Int Ed Engl. 56(46):14443-14447.

Xu Z, Gakhar L, Bain FE, Spies M, Fuentes EJ. (2017) The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain. J Biol Chem. 292(43):17777-17793.

Yadav RP, Gakhar L, Yu L, Artemyev NO. (2017) Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc Natl Acad Sci U S A. 114(32):E6536-E6545.

Pamela K. Geyer

Baxley, R.M., Bullard, J.D, Klein, M.W., Fell, A.G., Morales-Rosado, J.A., Duan, T. and Geyer, P.K. (2017) Deciphering the DNA code for the function of the Drosophila polydactyl zinc-finger protein Suppressor of Hairy-wing. Nucl. Acid Res., 45(8):4463-4478

Catherine A. Musselman

Gatchalian J, Wang X, Ikebe J, Cox KL, Tencer AH, Zhang Y, Burge NL, Di L, Gibson MD, Musselman CA, Poirier MG, Kono H, Hayes JJ, Kutateladze TG. (2017) Accessibility of the histone H3 tail in the nucleosome for binding of paired readers. Nat Commun. 8(1):1489.

Tencer AH, Cox KL, Di L, Bridgers JB, Lyu J, Wang X, Sims JK, Weaver TM, Allen HF, Zhang Y, Gatchalian J, Darcy MA, Gibson MD, Ikebe J, Li W, Wade PA, Hayes JJ, Strahl BD, Kono H, Poirier MG, Musselman CA, Kutateladze TG. (2017) Covalent Modifications of Histone H3K9 Promote Binding of CHD3. Cell Rep. 21(2):455-466.

Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, Gu BX, Crabtree GR, Musselman CA. (2017) DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes. Nat Commun. 8:16080.

Flenker KS, Burghardt EL, Dutta N, Burns WJ, Grover JM, Kenkel EJ, Weaver TM, Mills J, Kim H, Huang L, Owczarzy R, Musselman CA, Behlke MA, Ford B, McNamara JO 2nd. (2017) Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity.  Mol Ther. 25(6):1353-1362.

Andrew W. Norris

Sun X, Yi Y, Xie W, Liang B, Winter MC, He N, Liu X, Luo M, Yang Y, Ode KL, Uc A, Norris AW, Engelhardt JF.  (2017) CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived FactorsEndocrinology. 158(10):3325-3338.

Coryell WH, Langbehn DR, Norris AW, Yao JR, Dindo LN, Calarge CA. (2017) Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence. Psychiatry Res. 256:305-311.

Bryce V. Plapp

K Kim and BV Plapp. (2017) Inversion of Substrate Stereoselectivity of Horse Liver Alcohol Dehydrogenase by Substitutions of Ser-48 and Phe-93. Chem. Biol. Interact. 276,77-87.

BV Plapp, BR Savarimuthu, DJ Ferraro, JK Rubach, EN Brown, and S Ramaswamy. (2017) Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis. Biochemistry. 56, 3632-3646.

David H. Price

Bosque, A., Nilson, K.A., Macedo, A.B., Spivak, A.M., Archin, N., Van Wagoner, R.M., Martins, L.J., Novis, C.L., Szaniawski, M.A., Ireland, C.M., Margolis, D.M, Price, D.H., Planelles, V. (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Reports, 18:1324-1334.

Brogie, J.E and Price D.H. (2017) Reconstitution of a functional 7SK snRNP. Nucleic Acids Res. 45(11):6864-6880.

Nilson, K.A., Lawson, C.K., Mullen, N.J., Ball, C.B., Spector, B.M., Meier, J.L., Price, D.H. (2017) Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome. Nucleic Acids Res. 45(19):11088-11105.

Mullen, NJ and Price DH. (2017) Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function. PLoS ONE, 12(10):e0186423.

Miles Pufall

Rollins DA, Kharlyngdoh JB, Coppo M, Tharmalingam B, Mimouna S, Guo Z, Sacta MA, Pufall MA, Fisher RP, Hu X, Chinenov Y, Rogatsky I. (2017) Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat Commun. 8(1):1739.

Pufall MA. (2017) Defining Native Enhancer Function. Cell Syst. 5(4):310-312.

Michaelson JJ, Shin MK, Koh JY, Brueggeman L, Zhang A, Katzman A, McDaniel L, Fang M, Pufall M, Pieper AA. (2017) Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes. Biol Psychiatry. 82(3):213-223.

Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. (2017) Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.  Blood. 129(22):3000-3008.

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. (2017) Metabolic gatekeeper function of B-lymphoid transcription factors.  Nature. 542(7642):479-483.

Peter A. Rubenstein

Niederhoffer EC, Cline SD, Osheroff N, Simmons JM, Diekman AB, Franklin DS, Abali EE, Bateman RC Jr, Fontes JD, Lindsley JE, Pearson D, Rubenstein PA, Slaughter CA, Bernstein JA, Hyland KM, Park VM, Sobering AK, Weiler TA, Dasgupta S. (2017) Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6thInternational Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017. Med Sci Educ. 27(4):855-859.

Michael J. Schnieders

Lansdon LA, Bernabe HV, Nidey N, Standley J, Schnieders MJ, Murray JC. (2017) The Use of Variant Maps to Explore Domain-Specific Mutations of FGFR1. J Dent Res. 96(11):1339-1345.

Simpson A, Avdic A, Roos BR, DeLuca A, Miller K, Schnieders MJ, Scheetz TE, Alward WL, Fingert JH. (2017) LADD syndrome with glaucoma is caused by a novel gene.  Mol Vis. 23:179-184.

Madeline Shea

*Hovey, L., *Fowler, C.A., Mahling, R., Lin, Z., Miller, M.S. Marx, D.C., Yoder, J.B., Kim, E.H.,Tefft, K.M., Waite, B.C., Feldkamp, M.D., Yu, L., Shea, M.A. (2017) Calcium Triggers Reversal of Calmodulin on Nested Anti-Parallel Sties in the IQ Motif of the Neuronal Voltage- Dependent Sodium Channel NaV1.2 . Biophysical Chemistry, 224:1-19.

Fowler, C.A., Núñez Hernandez, M., O’Donnell, S.E., Yu, L., and Shea, M.A. (2017) Backbone and Side-Chain Resonance Assignments of (Ca2+)4-Calmodulin Bound to Beta Calcineurin A CaMBD Peptide. Biomolecular NMR Assignments, 11:275–28

Mahling, R., Kilpatrick, A. M., and Shea, M.A. Backbone resonance assignments of complexes of human voltage-dependent sodium channel NaV1.2 IQ motif peptide bound to apo calmodulin and to the C-domain fragment of apo calmodulin. Biomolecular NMR Assignments, 11:297–303.

M. Ashley Spies

Vance, N.R, Gakhar, L., and Spies, M.A. (2017) Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery ApproachAngew Chem Int Ed. Eng. 56(46):14443-14447.

Hengel, S.R., Spies, M.A.*, and Spies, M.* (2017) Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem. Bio. 24(9):1101-1119.

Maria Spies

Hengel, S.R., Spies, M.A.*, and Spies, M.* (2017) Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem. Bio. 24(9):1101-1119.

Caldwell CC, Spies M. (2017) Helicase SPRNTing through the nanopore. Proc Natl Acad Sci U S A. 114(45):11809-11811.

Xu Z., Gakhar L., Bain F.E., Spies M. and Fuentes E.J. (2017) Tiam1 auto-inhibition by the N-terminal PHn-CC-Ex domain. J Biol Chem. 292(43):17777-17793.

Spies M, Smith BO. (2017) Protein-nucleic acids interactions: new ways of connecting structure, dynamics and function. Biophys Rev. 9(4):289-291.

Spies M. (2017) A time for promiscuity in a eukaryotic recombinase. J Biol Chem. 292(26):11136-11137.

Nancy C. Stellwagen

Stellwagen NC. (2017) Electrophoretic Mobilities of the Charge Variants of DNA and Other Polyelectrolytes: Similarities, Differences, and Comparison with Theory. J Phys Chem B. 121(9):2015-2026.

Eric B. Taylor

Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB. (2017) The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab. 6(11):1468-1479.

Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN. (2017) The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 102(8):985-999.

DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT. (2017) ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Rep. 19(9):1794-1806.

Taylor EB. (2017) Functional Properties of the Mitochondrial Carrier System. Trends Cell Biol. 27(9):633-644.

M. Todd Washington

Zhoa, L. and Washington, M. T. (2017) Translesion synthesis: Insights into the selection and switching of DNA polymerases. Genes, 8(1), e24.

Liu, J., Ede, C., Wright, W. D., Gore, S. K., Jenkins, S. S., Freudenthal, B. D., Washington, M. T., Veaute, X., and Heyer, W. D. (2017) Srs2 promotes synthesis-dependent strand annealing by disruptiong DNA polymerase delta-extending D-loops. eLife 6, e22195.

Powers, K. T. and Washington, M. T. (2017) Analyzing the catalytic activities and interactions of eukaryotic translesion synthesis. Methods Enzymol. 592, 329-356.

Ronald J. Weigel

De Andrade JP, Lorenzen AW, Wu VT, Bogachek MV, Park JM, Gu VW, Sevenich CM, Cassady VC, Beck AC, Kulak MV, Robinson RA, Lal G, Weigel RJ. (2017) Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer. Oncotarget. 8(70):114801-114815.

Wu VT, Lorenzen AW, Beck AC, Reid VJ, Sugg SL, Howe JR, Pollard JH, Lal G, Weigel RJ. (2017) Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease. Surgery. 161(1):147-155.

Gómez-Contreras P, Ramiro-Díaz JM, Sierra A, Stipp C, Domann FE, Weigel RJ, Lal G. (2017) Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases. Clin Exp Metastasis. 34(1):37-49.

Thomas A, Weigel RJ, Lynch CF, Spanheimer PM, Breitbach EK, Schroeder MC. (2017) Incidence, characteristics, and management of recently diagnosed, microscopically invasive breast cancer by receptor status: Iowa SEER 2000 to 2013. Am J Surg. 214(2):323-328.

Marc S. Wold

Zhang, H., Gan, H., Wang, Z. Lee, J-H., Zhou, H. Ordog, T., Wold, M.S., Ljungman, M., Zhang, Z. (2017) RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells. Molecular Cell 65, 272-282.

Meng Wu

Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller M, Tian J, Zhu J, Xu J, Wen M, Er-Bu A, Wang J, Xiao Y, Wu M, McManus OB, Li M, Wu J, Luo HR, Cao Z, Shen B, Wang H, Zhu MX, Hong X. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem. 60(11):4680-4692.

Liping Yu

Fowler, C.A., Núñez Hernandez, M., O’Donnell, S.E., Yu, L., and Shea, M.A. (2017) Backbone and Side-Chain Resonance Assignments of (Ca2+)4-Calmodulin Bound to Beta Calcineurin A CaMBD Peptide. Biomolecular NMR Assignments, 11:275–280.

Yadav RP, Gakhar L, Yu L, Artemyev NO. (2017) Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc Natl Acad Sci U S A. 114(32):E6536-E6545.

B. Fink, F. Bai, L. Yu, and W. Sivitz. (2017) Regulation of ATP production: dependences on calcium concentration and respiratory state. American Journal of Physiology – Cell Physiology, 313, C146-C153. DOI: 10.1152/ajpcell.00086.2017.

L. Yu, R.P. Yadav, and N.O. Artemyev. (2017) NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand. Biomol. NMR Assign., 11, 111-115. DOI: 10.1007/s12104-017-9730-2.

*Hovey, L., *Fowler, C.A., Mahling, R., Lin, Z., Miller, M.S. Marx, D.C., Yoder, J.B., Kim, E.H.,Tefft, K.M., Waite, B.C., Feldkamp, M.D., Yu, L., Shea, M.A. (2017) Calcium Triggers Reversal of Calmodulin on Nested Anti-Parallel Sties in the IQ Motif of the Neuronal Voltage-Dependent Sodium Channel NaV1.2 . Biophysical Chemistry, 224:1-19.

2016 Publications

Wednesday, March 1st, 2017

The Department’s 2016 publications are now in print and mostly available online.

E. Dale Abel

Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. (2016) Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 157(1):336-45. DOI: 10.1210/en.2015-1709. PMID: 26469138

Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T. (2016) Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes. 65(1):255-68. DOI: 10.2337/db15-0963. PMID: 26470784

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ. (2016) Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circulation research. DOI: 10.1161/RES.0000000000000097. PMID: 27012580

Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, Riehle C. (2016) Exercise training improves vascular mitochondrial function. American Journal of Physiology, Heart and Circulatory Physiology. 310(7):H821-9. DOI: 10.1152/ajpheart.00751.2015. PMID: 26825520

Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. (2016) AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell metabolism. 23(4):649-62. DOI: 10.1016/j.cmet.2016.03.008. PMID: 27076078

Jaishy B, Abel ED. (2016) Lipids, Lysosomes and Autophagy. Journal of lipid research. DOI: 10.1194/jlr.R067520. PMID: 27330054

O’Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. (2016) Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. The Journal of clinical investigation. 126(9):3433-46. DOI: 10.1172/JCI86522. PMID: 27525440

Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM. (2016) The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis. Breast cancer research : BCR. 18(1):131. DOI: 10.1186/s13058-016-0795-0. PMID: 27998284

Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li  Z, Abel ED, Migaud ME, Brenner C. (2016) Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature communications. 7:12948. DOI: 10.1038/ncomms12948. PMID: 27721479

Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West TM, Anderson EJ, Wei W, Abel ED, Xiang YK. (2016) Inhibiting Insulin-Mediated β2AR Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. DOI: 10.1161/CIRCULATIONAHA.116.022281. PMID: 27815373

Charles M. Brenner

Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C. (2016) Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk. J Nutr. 146(5):957-63. DOI: 10.3945/jn.116.230078. PMID: 27052539

Trammell SA, Weidemann BJ, Chadda A, Yorek MS, Holmes A, Coppey LJ, Obrosov A, Kardon RH, Yorek MA, Brenner C. (2016) Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice. Sci Rep. 6:26933. DOI: 10.1038/srep26933. PMID: 27230286

Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. (2016) Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 7:12948. DOI: 10.1038/ncomms12948. PMID: 27721479

Ratajczak J, Joffraud M, Trammell SA, Ras R, Canela N, Boutant M, Kulkarni SS, Rodrigues M, Redpath P, Migaud ME, Auwerx J, Yanes O, Brenner C, Cantó C. (2016) NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun. 7:13103. DOI: 10.1038/ncomms13103. PMID: 27725675

John M. Dagle

Patel PM, Momany AM, Schaa KL, Romitti PA, Druschel C, Cooper ME, Marazita ML, Murray JC, Dagle JM. (2016) Genetic Modifiers of Patent Ductus Arteriosus in Term Infants. J Pediatr.  176:57-61.e1. DOI: 10.1016/j.jpeds.2016.05.066. PMID: 27344223

Smazal AL, Kavars AB, Carlson SJ, Colaizy TT, Dagle JM. (2016) Peripherally inserted central catheters optimize nutrient intake in moderately preterm infants. Pediatr Res. 80(2):185-9. DOI: 10.1038/pr.2016.73. PMID: 27057735

Ryckman KK, Berberich SL, Dagle JM. (2016) Predicting gestational age using neonatal metabolic markers. Am J Obstet Gynecol. 214(4):515.e1-13. DOI: 10.1016/j.ajog.2015.11.028. PMID: 26645954

Sampath V, Helbling D, Menden H, Dimmock D, Mulrooney NP, Murray JC, Dagle JM, Garland JS. (2016) Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants. J Pediatr Gastroenterol Nutr. 62(3):420-3. DOI: 10.1097/MPG.0000000000000988. PMID: 26426434

Kaluarachchi DC, Momany AM, Busch TD, Gimenez LG, Saleme C, Cosentino V, Christensen K, Dagle JM, Ryckman KK, Murray JC. (2016) Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth. Pediatr Res. 79(5):776-80. DOI: 10.1038/pr.2016.7. PMID: 26761123

Adrian H. Elcock

Lay WK, Miller MS, Elcock AH. (2016) Optimizing Solute-Solute Interactions in the GLYCAM06 and CHARMM36 Carbohydrate Force Fields Using Osmotic Pressure Measurements. J Chem Theory Comput. 12(4):1401-7. DOI: 10.1021/acs.jctc.5b01136. PMID: 26967542

Miller MS, Lay WK, Elcock AH. (2016) Osmotic Pressure Simulations of Amino Acids and Peptides Highlight Potential Routes to Protein Force Field Parameterization. J Phys Chem B. 120(33):8217-29. DOI: 10.1021/acs.jpcb.6b01902. PMID: 27052117

Chen R, Subramanyam S, Elcock AH, Spies M, Wold MS. (2016) Dynamic binding of replication protein a is required for DNA repair. Nucleic Acids Res. 44(12):5758-72. DOI: 10.1093/nar/gkw339. PMID: 27131385

Clark PL, Elcock AH. (2016) Molecular chaperones: providing a safe place to weather a midlife protein-folding crisis. Nat Struct Mol Biol. 23(7):621-3. DOI: 10.1038/nsmb.3255. PMID: 27384188

Ernesto J. Fuentes

Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. (2016) Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure. 24(12):2053-2066. DOI: 10.1016/j.str.2016.08.019. PMID: 27998539

Lokesh Gakhar

Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. (2016) Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure. 24(12):2053-2066. DOI: 10.1016/j.str.2016.08.019. PMID: 27998539

Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS.(2016) Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 7:13180. DOI: 10.1038/ncomms13180. PMID: 27779193

Hastie JL, Williams KB, Bohr LL, Houtman JC, Gakhar L, Ellermeier CD. (2016) The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation. PLoS Genet. 12(9):e1006287. DOI: 10.1371/journal.pgen.1006287. PMID: 27602573

Gakhar L, Bassuk AG, Velez G, Khan S, Yang J, Tsang SH, Mahajan VB. (2016) Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains. J Struct Biol. 196(3):309-318. DOI: 10.1016/j.jsb.2016.07.017. PMID: 27474374

Guo Q, Gakhar L, Wickersham K, Francis K, Vardi-Kilshtain A, Major DT, Cheatum CM, Kohen A. (2016) Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii. Biochemistry. 55(19):2760-71. DOI: 10.1021/acs.biochem.6b00181. PMID: 27100912

Pamela K. Geyer

Barton LJ, Lovander KE, Pinto BS, Geyer PK. (2016) Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin. Developmental Biology. 415(1):75-86. PMID: 27174470

Berger F, Geyer PK. (2016) Editorial overview: Genome architecture and expression: Connecting genome composition and nuclear architecture with function. Curr Opin Genet Dev. 37:iv-vi. DOI: 10.1016/j.gde.2016.05.017. PMID: 27292868

Catherine A. Musselman

Musselman CA, Kutateladze TG. (2016) Preparation, Biochemical Analysis, and Structure Determination of Methyllysine Readers. Methods Enzymol. 573:345-62. DOI: 10.1016/bs.mie.2015.12.005. PMID: 27372761

Xing S, Li F, Zeng Z, Zhao Y, Yu S, Shan Q, Li Y, Phillips FC, Maina PK, Qi HH, Liu C, Zhu J, Pope RM, Musselman CA, Zeng C, Peng W, Xue HH. (2016) Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 17(6):695-703. DOI: 10.1038/ni.3456. PMID: 27111144

Andrew W. Norris

Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD. (2016) Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology. 157(11):4266-4275. PMID: 27575030

Yi Y, Norris AW, Wang K, Sun X, Uc A, Moran A, Engelhardt JF, Ode KL. (2016) Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis. Am J Respir Crit Care Med. 194(8):974-980. PMID: 27447840

Yi Y, Sun X, Gibson-Corley K, Xie W, Liang B, He N, Tyler SR, Uc A, Philipson LH, Wang K, Hara M, Ode KL, Norris AW, Engelhardt JF. (2016) A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology. 157(5):1852-65. DOI: 10.1210/en.2015-1935. PMID: 26862997

Bryce V. Plapp

Plapp BV, Charlier HA Jr, Ramaswamy S. (2016) Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol. Arch Biochem Biophys. 591:35-42. DOI: 10.1016/j.abb.2015.12.009. PMID:26743849

David H. Price

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI. (2016) Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 62(1):34-46. DOI: 10.1016/j.molcel.2016.03.013. PMID: 27058786

Peter A. Rubenstein

Lee CY, Lou J, Wen KK, McKane M, Eskin SG, Rubenstein PA, Chien S, Ono S, Zhu C, McIntire LV. (2016) Regulation of actin catch-slip bonds with a RhoA-formin module.  Sci Rep. 6:35058.  DOI: 1038/srep35058. PMID: 27731359

Jepsen L, Kruth KA, Rubenstein PA, Sept D. (2016) Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure.  Biophys J. 111(2):323-32. DOI: 10.1016/j.bpj.2016.06.012. PMID: 27463135

Jepsen L, Kruth KA, Rubenstein PA, Sept D. (2016) Molecular Effects of Deafness Mutations in Actin.  Biophys J. 1110(2):354a.

Michael J. Schnieders

Bell DR, Qi R, Jing Z, Xiang JY, Mejias C, Schnieders MJ, Ponder JW, Ren P. (2016) Calculating binding free energies of host-guest systems using the AMOEBA polarizable force field. Phys Chem Chem Phys. 18(44):30261-30269. PMID: 27254477

Bu F, Borsa NG, Jones MB, Takanami E, Nishimura C, Hauer JJ, Azaiez H, Black-Ziegelbein EA, Meyer NC, Kolbe DL, Li Y, Frees K, Schnieders MJ, Thomas C, Nester C, Smith RJ. (2016) High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies. J Am Soc Nephrol. 27(4):1245-53. DOI: 10.1681/ASN.2015040385. PMID: 26283675

DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC. (2016) Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. Hum Mol Genet. 25(1):44-56. DOI: 10.1093/hmg/ddv446. PMID: 26494905

Nessler IJ, Litman JM, Schnieders MJ. (2016) Toward polarizable AMOEBA thermodynamics at fixed charge efficiency using a dual force field approach: application to organic crystals. Phys Chem Chem Phys. 18(44):30313-30322. PMID: 27524378

Debra A. Schwinn

Schwinn DA. (2016) EDUCATE TO TRANSFORM: THE ART OF DEVELOPING CURIOUS MINDS. Trans Am Clin Climatol Assoc. 127:259-271. PMID: 28066058

M. Ashley Spies

Hengel SR, Malacaria E, Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA, Spies M. (2016) Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. Elife. 5. pii: e14740. DOI: 10.7554/eLife.14740. PMID: 27434671

Maria Spies

Spies M, Chemla YR. (2016) Single-molecule enzymology: fluorescence-based and high-throughput methods. Methods in enzymology. Elsevier. 581. ISSN 0076-6879

Boehm EM, Powers KT, Kondratick CM, Spies M, Houtman JC, Washington MT. (2016) The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1. J Biol Chem. 291(16):8735-44. DOI: 10.1074/jbc.M115.697938. PMID: 26903512

Boehm EM, Spies M, Washington MT. (2016) PCNA tool belts and polymerase bridges form during translesion synthesis. Nucleic Acids Res. 44(17):8250-60. DOI: 10.1093/nar/gkw563. PMID: 27325737

Chen R, Subramanyam S, Elcock AH, Spies M, Wold MS. (2016) Dynamic binding of replication protein a is required for DNA repair.  Nucleic Acids Res. 44(12):5758-72. DOI: 10.1093/nar/gkw339. PMID: 27131385

Bain FE, Wu CG, Spies M. (2016) Single-molecule sorting of DNA helicases. Methods. 108:14-23. DOI: 10.1016/j.ymeth.2016.05.009. PMID: 27223403

Hengel SR, Malacaria E, Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA, Spies M. (2016) Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. Elife. 5. pii: e14740. DOI: 10.7554/eLife.14740. PMID: 27434671

Subramanyam S, Ismail M, Bhattacharya I, Spies M. (2016) Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics. Proc Natl Acad Sci U S A. 113(41):E6045-E6054. PMID: 27671650

Wu CG, Spies M. (2016) G-quadruplex recognition and remodeling by the FANCJ helicase. Nucleic Acids Res. 44(18):8742-8753. PMID: 27342280

Boehm EM, Subramanyam S, Ghoneim M, Washington MT, Spies M. (2016) Quantifying the Assembly of Multicomponent Molecular Machines by Single-Molecule Total Internal Reflection Fluorescence Microscopy. Methods Enzymol. 581:105-145. DOI: 10.1016/bs.mie.2016.08.019. PMID: 27793278

Eric B. Taylor

Gray LR, Rauckhorst AJ, Taylor EB. (2016) A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity. J Biol Chem. 291(14):7409-17. DOI: 10.1074/jbc.M115.711663.PMID: 26823462

Rauckhorst AJ, Taylor EB. (2016) Mitochondrial pyruvate carrier function and cancer metabolism. Curr Opin Genet Dev. 38:102-109. DOI: 10.1016/j.gde.2016.05.003. Review. PMID: 27269731

Lori L. Wallrath

Wallrath LL, Bohnekamp J, Magin TM. (2016) Cross talk between the cytoplasm and nucleus during development and disease. Curr Opin Genet Dev. 37:129-36. DOI: 10.1016/j.gde.2016.03.007. PMID: 27110666

Bohnekamp J, Cryderman DE, Thiemann DA, Magin TM, Wallrath LL. (2016) Using Drosophila for Studies of Intermediate Filaments. Methods Enzymol. 568:707-26. DOI: 10.1016/bs.mie.2015.08.028. PMID: 26795490

M. Todd Washington

Boehm EM, Powers KT, Kondratick CM, Spies M, Houtman JC, Washington MT. (2016) The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1. J Biol Chem. 291(16):8735-44. DOI: 10.1074/jbc.M115.697938. PMID: 26903512

Boehm EM, Gildenberg MS, Washington MT. (2016) The Many Roles of PCNA in Eukaryotic DNA Replication. Enzymes. 39:231-54. DOI: 10.1016/bs.enz.2016.03.003. PMID: 27241932

Boehm EM, Spies M, Washington MT. (2016) PCNA tool belts and polymerase bridges form during translesion synthesis. Nucleic Acids Res. 44(17):8250-60. DOI: 10.1093/nar/gkw563. PMID: 27325737

Kondratick CM, Boehm EM, Dieckman LM, Powers KT, Sanchez JC, Mueting SR, Washington MT. (2016) Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis. PLoS One. 11(6):e0157023. DOI: 10.1371/journal.pone.0157023. PMID: 27258147

Boehm EM, Washington MT. (2016) R.I.P. to the PIP: PCNA-binding motif no longer considered specific: PIP motifs and other related sequences are not distinct entities and can bind multiple proteins involved in genome maintenance. Bioessays. 38(11):1117-1122. DOI: 10.1002/bies.201600116. PMID: 27539869

Washington MT. (2016) DNA Polymerase Fidelity: Beyond Right and Wrong. Structure. 24(11):1855-1856. DOI: 10.1016/j.str.2016.10.003. PMID: 27806256

Boehm EM, Subramanyam S, Ghoneim M, Washington MT, Spies M. (2016) Quantifying the Assembly of Multicomponent Molecular Machines by Single-Molecule Total Internal Reflection Fluorescence Microscopy. Methods Enzymol. 581:105-145. DOI: 10.1016/bs.mie.2016.08.019. PMID: 27793278

Daniel l. Weeks

Gazdag E, Jacobi UG, van Kruijsbergen I, Weeks DL, Veenstra GJ. (2016) Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors. Development (Cambridge, England). 143(8):1340-50. PMID: 26952988

Hayes MH, Weeks DL. (2016) Amyloids assemble as part of recognizable structures during oogenesis in Xenopus. Biology open. 5(6):801-6. PMID: 27215327

Ronald J. Weigel

De Andrade JP, Park JM, Gu VW, Woodfield GW, Kulak MV, Lorenzen AW, Wu VT, Van Dorin, SE, Spanheimer PM, Weigel RJ. (2016) EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib. Molecular Cancer Therapeutics. 15:503-11. PMID: 26832794

Bogachek MV, Park JM, De Andrade JP, Lorenzen AW, Kulak MV, White JR, Gu VW, Wu VT, Weigel RJ. (2016) Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports. 7:1140-1151. PMID: 27916539

Rosengart TK, Kent KC, Bland KI, Britt LD, Eberlein TJ, Gewertz BL, Hunter JG, Lillemoe KD, Pellegrini CA, Schulick RD, Stain SC, Weigel RJ. (2016) Key Tenets of Effective Surgery Leadership: Perspectives from the Society of Surgical Chairs Mentorship Sessions. JAMA Surg. 151:768-70. PMID: 27096328

Thomas A, Weigel RJ, Lynch CF, Spanheimer PM, Breitbach EK, Schroeder MC (2016). Incidence, Characteristics and Management of Recently Diagnosed, Microscopically Invasive Breast Cancer by Receptor Status: Iowa SEER 2000-2013. American Journal of Surgery. pii: S0002-9610(16)30504-9. DOI: 10.1016/j.amjsurg.2016.08.008.

Marc S. Wold

Myler LR, Gallardo IF, Zhou Y, Gong F, Yang SH, Wold MS, Miller KM, Paull TT, Finkelstein IJ. (2016) Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins. Proc Natl Acad Sci U S A. 113(9):E1170-9. DOI: 10.1073/pnas.1516674113. PMID: 26884156

Chen R, Subramanyam S, Elcock AH, Spies M, Wold MS. (2016) Dynamic binding of replication protein a is required for DNA repair.  Nucleic Acids Res. 44(12):5758-72. DOI: 10.1093/nar/gkw339. PMID: 27131385

Meng Wu

Hengel SR, Malacaria E, Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA, Spies M. (2016) Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. Elife. 5. pii: e14740. DOI: 10.7554/eLife.14740. PMID: 27434671

Liping Yu

Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. (2016) Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure. 24(12):2053-2066. DOI: 10.1016/j.str.2016.08.019. PMID: 27998539

Fink BD, Bai F, Yu L, Sivitz WI. (2016) Impaired utilization of membrane potential by complex II-energized mitochondria of obese, diabetic mice assessed using ADP recycling methodology.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 311, R756-R763.  DOI: 10.1152/ajpregu.00232.2016. PMID: 27558314

Zhu Q, Venzke D, Walimbe AS, Anderson ME, Fu Q, Kinch LN, Wang W, Chen X, Grishin NV, Huang N, Yu L, Dixon JE, Campbell KP, Xiao J. (2016) Structure of protein O-mannose kinase reveals a unique active site architecture.  eLife. 5, e22238.  DOI: 10.7554/eLife.22238. PMID: 27879205

Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP. (2016) Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat. Chem. Biol. 12(10), 810-814. DOI:10.1038/nchembio.2146. PMID: 27526028

Hengel SR, Malacaria E, Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA, Spies M. (2016) Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. Elife. 5. pii: e14740. DOI: 10.7554/eLife.14740. PMID: 27434671

Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C. (2016) Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk. J Nutr. 146(5):957-63. DOI: 10.3945/jn.116.230078. PMID: 27052539

Bai F, Fink BD, Yu L, Sivitz WI. (2016) Voltage-dependent regulation of complex II energized mitochondrial oxygen flux. PLoS One. 11(5):e0154982. DOI:10.1371/journal.pone.0154982. PMID: 27153112

Mishanina TV, Yu L, Karunaratne K, Mondal D, Corcoran JM, Choi MA, Kohen A. (2016) An unprecedented mechanism of nucleotide methylation in organisms containing thyX. Science. 351 (6272), 507-510.  DOI:

Lacy Barton wins 2016 Clarence Berg Award

Thursday, November 17th, 2016

Lacy Barton, a 2014 PhD with Dr. Pamela Geyer, has been named the winner of the 2016 Clarence Berg Award. The Berg Award is given biennially in honor of our former Professor Clarence P. Berg to the graduate student who demonstrates “scholarship, integrity, cooperativeness, consideration and a willingness to help others.”

Lacy was also recently named the winner of the 2015 Subramanian Award for best PhD thesis in the Department of Biochemistry.  Lacy is currently a postdoctoral fellow in Ruth Lehmann’s laboratory at New York University School of Medicine in New York, NY. She was awarded a Damon Runyon Cancer Research Foundation Fellowship for her project entitled “Mechanisms of directed cell migration in a complex in vivo environment.” Damon Runyon fellowships are among the most recognized postdoctoral awards and a high accolade for an early career scientist. Congratulations, Dr. Barton!

2016 Biochemistry Newsletter now available

Friday, November 4th, 2016

2016_newslettercoverimageThe 2016 Biochemistry @ Iowa newsletter is hot off the presses and available for download. Alumni and friends should receive a hard copy in the mail this week. If you would like to be added to our mailing list, please send your contact information to biochem@uiowa.edu. While you are at it, feel free to send us your news and updates! Previous newsletters are also available online.

2015 Publications

Wednesday, March 16th, 2016

The Department’s 2015 publications are now in print and mostly available online.

E. Dale Abel

Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED. (2015) Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 56(3):546-61. DOI: 10.1194/jlr.M055152. PMID: 25529920

Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. (2015) GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 18(4):521-30. DOI: 10.1038/nn.3966. PMID: 25730668

Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H. (2015) Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol. 110(4):37. DOI: 10.1007/s00395-015-0495-4. PMID: 25982881

Ilkun O, Wilde N, Tuinei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. (2015) Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol. 85:104-16. DOI: 10.1016/j.yjmcc.2015.05.012. PMID: 26004364

Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. (2015) Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci USA. 112(29):9129-34. DOI: 10.1073/pnas.1504705112. PMID: 26153425

Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK. (2015) Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest. 125(9):3461-76. DOI: 10.1172/JCI79964. PMID: 26241060

Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD. (2015) Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo. Diabetes. 64(11):3914-26. DOI: 10.2337/db15-0244. PMID: 26253611

Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. (2015) Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 162(6):1217-28. DOI: 10.1016/j.cell.2015.08.012. PMID: 26321681

Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. (2015) Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 157(1):336-45. DOI: 10.1210/en.2015-1709. PMID: 26469138

Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T. (2015) Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes. 65(1):255-68. DOI: 10.2337/db15-0963. PMID: 26470784

Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED.( 2015) Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations. J Mol Cell Cardiol. 89(Pt B):297-305. DOI: 10.1016/j.yjmcc.2015.10.015. PMID: 26476238

Sheila A. Baker

Pan Y, Laird JG, Yamaguchi DM, Baker SA. (2015) An N-Terminal ER Export Signal Facilitates the Plasma Membrane Targeting of HCN1 Channels in Photoreceptors. Invest Ophthalmol Vis Sci. 56(6):3514-21. DOI: 10.1167/iovs.15-16902. PMID: 26030105

Laird JG, Pan Y, Modestou M, Yamaguchi DM, Song H, Sokolov M, Baker SA. (2015) Identification of a VxP Targeting Signal in the Flagellar Na(+) /K(+) -ATPase. Traffic. 16(12):1239-53. DOI: 10.1111/tra.12332. PMID: 26373354

Cao Y, Sarria I, Fehlhaber KE, Kamasawa N, Orlandi C, James KN, Hazen J, Gardner MR, Farzan M, Lee A, Baker SA, Baldwin K, Sampath AP, Martemyanov KA. (2015) Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision. Neuron. 87(6):1248-60. PMID: 26402607

Charles M. Brenner

Trammell SA, Brenner C. (2015) NNMT: A Bad Actor in Fat Makes Good in Liver. Cell Metab. 22(2):200-1. DOI: 10.1016/j.cmet.2015.07.017. PMID: 26244929

Mei SC, Brenner C. (2015) Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous. PLoS Biol. 13(1):e1002048. DOI: 10.1371/journal.pbio.1002048. PMID: 25633578

John M. Dagle

Waleh N, Barrette AM, Dagle JM, Momany A, Jin C, Hills NK, Shelton EL, Reese J, Clyman RI. (2015) Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression. J Pediatr. 167(5):1033-1041.e2. DOI: 10.1016/j.jpeds.2015.07.011. PMID: 26265282

Sampath V, Helbling D, Menden H, Dimmock D, Mulrooney NP, Murray JC, Dagle JM, Garland JS. (2015) Necrotizing Enterocolitis is Not Associated with Sequence Variants in Anti-Oxidant Response Genes in Premature Infants.J Pediatr Gastroenterol Nutr. PMID: 26426434

Ryckman KK, Berberich SL, Dagle JM. (2015) Predicting gestational age by the use of neonatal metabolic markers. Am J Obstet Gynecol. pii: S0002-9378(15)02401-1. DOI: 10.1016/j.ajog.2015.11.028. PMID: 26645954

Kaluarachchi DC, Momany AM, Busch TD, Gimenez LG, Saleme C, Cosentino V, Christensen K, Dagle JM, Ryckman KK, Murray JC. (2015) Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth. Pediatr Res. DOI: 10.1038/pr.2016.7. PMID: 26761123

Brandon S. Davies

Beigneux AP, Fong LG, Bensadoun A, Davies BS, Oberer M, Gårdsvoll H, Ploug M, Young SG. (2015) GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ Res. 116(4):624-32. DOI: 10.1161/CIRCRESAHA.116.305085. PMID: 25387803

Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. (2015) Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1.J Biol Chem. 290(19):11865-77. DOI: 10.1074/jbc.M114.623769. PMID: 25809481

Kris A. DeMali

Jannie K, Ellerbroek SM, Zhou DW, Chen S, Crompton DJ, Garcia AJ, DeMali KA (2015) Vinculin-dependent actin bundling regulates cell migration and traction forces. Biochem. J. 465 (3) 383-393. DOI: 10.1042/BJ20140872. PMID: 25358683

Adrian H. Elcock

Li S, Elcock AH. (2015) Residue-Specific Force Field (RSFF2) Improves the Modeling of Conformational Behavior of Peptides and Proteins. J Phys Chem Lett. 6(11):2127-33. DOI: 10.1021/acs.jpclett.5b00654. PMID: 26266514

Cressiot B, Braselmann E, Oukhaled A, Elcock AH, Pelta J, Clark PL. (2015) Dynamics and Energy Contributions for Transport of Unfolded Pertactin through a Protein Nanopore. ACS Nano. 9(9):9050-61. DOI: 10.1021/acsnano.5b03053. PMID: 26302243

Brown RF, Andrews CT, Elcock AH. (2015) Stacking Free Energies of All DNA and RNA Nucleoside Pairs and Dinucleoside-Monophosphates Computed Using Recently Revised AMBER Parameters and Compared with Experiment. J Chem Theory Comput. 11(5):2315-28. DOI: 10.1021/ct501170h.PMID:26574427

Frembgen-Kesner T, Andrews CT, Li S, Ngo NA, Shubert SA, Jain A, Olayiwola OJ, Weishaar MR, Elcock AH. (2015) Parametrization of Backbone Flexibility in a Coarse-Grained Force Field for Proteins (COFFDROP) Derived from All-Atom Explicit-Solvent Molecular Dynamics Simulations of All Possible Two-Residue Peptides. J Chem Theory Comput. 11(5):2341-54. DOI: 10.1021/acs.jctc.5b00038. PMID: 26574429

Li S, Andrews CT, Frembgen-Kesner T, Miller MS, Siemonsma SL, Collingsworth TD, Rockafellow IT, Ngo NA, Campbell BA, Brown RF, Guo C, Schrodt M, Liu YT, Elcock AH. (2015) Molecular Dynamics Simulations of 441 Two-Residue Peptides in Aqueous Solution: Conformational Preferences and Neighboring Residue Effects with the Amber ff99SB-ildn-NMR Force Field. J Chem Theory Comput. 11(3):1315-29. DOI: 10.1021/ct5010966. PMID: 26579777

Schrodt MV, Andrews CT, Elcock AH. (2015) Large-Scale Analysis of 48 DNA and 48 RNA Tetranucleotides Studied by 1 μs Explicit-Solvent Molecular Dynamics Simulations. J Chem Theory Comput. 11(12):5906-17. DOI: 10.1021/acs.jctc.5b00899. PMID: 26580891

Lokesh Gakhar

Yadav RP, Majumder A, Gakhar L, Artemyev NO. (2015) Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease. J Neurochem. 135(1):165-75. DOI: 10.1111/jnc.13223. PMID: 26139345

Wert KJ, Bassuk AG, Wu WH, Gakhar L, Coglan D, Mahajan M, Wu S, Yang J, Lin CS, Tsang SH, Mahajan VB. (2015) CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model. Hum Mol Genet. 24(16):4584-98. DOI: 10.1093/hmg/ddv189. PMID: 25994508

Bassuk AG, Yeh S, Wu S, Martin DF, Tsang SH, Gakhar L, Mahajan VB. (2015) Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment. PLoS One. 10(4):e0122352. DOI: 10.1371/journal.pone.0122352. PMID: 25856303

Feldkamp MD, Gakhar L, Pandey N, Shea MA. (2015) Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin. Proteins. 83(5):989-96. DOI: 10.1002/prot.24781. PMID: 25694384

Cho C, Chande A, Gakhar L, Bakaletz LO, Jurcisek JA, Ketterer M, Shao J, Gotoh K, Foster E, Hunt J, O’Brien E, Apicella MA. (2015) Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms. Infect Immun. 83(3):950-7. DOI: 10.1128/IAI.02601-14. PMID: 25547799

Doron D, Stojković V, Gakhar L, Vardi-Kilshtain A, Kohen A, Major DT. (2015) Free energy simulations of active-site mutants of dihydrofolate reductase. J Phys Chem B. 119(3):906-16. doi: 10.1021/jp5059963. PMID: 25382260

Pamela K. Geyer

Barton LJ, Soshnev AA, Geyer PK. (2015) Networking in the nucleus: a spotlight on LEM-domain proteins. Curr Opin Cell Biol. 34:1-8. DOI: 10.1016/j.ceb.2015.03.005.PMID: 25863918

Catherine A. Musselman

Tong Q, Cui G, Botuyan MV, Rothbart SB, Hayashi R, Musselman CA, Singh N, Appella E, Strahl BD, Mer G, Kutateladze TG. (2015) Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure. 23(2):312-21. DOI: 10.1016/j.str.2014.11.013. PMID: 25579814

Andrew W. Norris

Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW. (2015) Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clin Sci (Lond). 128(2):131-42. DOI: 10.1042/CS20140059. PMID: 25142104

Morgan DA, McDaniel LN, Yin T, Khan M, Jiang J, Acevedo MR, Walsh SA, Ponto LL, Norris AW, Lutter M, Rahmouni K, Cui H. (2015) Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus. Diabetes. 64(6):1976-87. DOI: 10.2337/db14-1257. PMID: 25605803

Gordon EE, Reinking BE, Hu S, Yao J, Kua KL, Younes AK, Wang C, Segar JL, Norris AW. (2015) Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. J Diabetes Res. 2015:479565. DOI: 10.1155/2015/479565. PMID: 26064981

Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB. (2015) Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell Metab. 22(4):669-81. DOI: 10.1016/j.cmet.2015.07.027. PMID: 26344103

Sawatzke AB, Norris AW, Spyropoulos F, Walsh SA, Acevedo MR, Hu S, Yao J, Wang C, Sunderland JJ, Boles Ponto LL. (2015) PET/CT imaging reveals unrivaled placental avidity for glucose compared to other tissues. Placenta. 36(2):115-20. DOI: 10.1016/j.placenta.2014.12.009. PMID: 25555498

Bryce V. Plapp

Plapp BV, Leidal KG, Murch BP, Green DW. (2015) Contribution of liver alcohol dehydrogenase to metabolism of alcohols in rats. Chem Biol Interact. 234:85-95. DOI: 10.1016/j.cbi.2014.12.040. PMID: 25641189

David H. Price

Nilson KA, Guo J, Turek ME, Brogie JE, Delaney E, Luse DS, Price DH. (2015) THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 59(4):576-87. DOI: 10.1016/j.molcel.2015.06.032. PMID: 26257281

Miles A. Pufall

Fontana MF, Baccarella A, Pancholi N, Pufall MA, Herbert DR, Kim CC. (2015) JUNB is a key transcriptional modulator of macrophage activation. J Immunol. 194(1):177-86.DOI: 10.4049/jimmunol.1401595. PMID: 25472994

Sasse SK, Zuo Z, Kadiyala V, Zhang L, Pufall MA, Jain MK, Phang TL, Stormo GD, Gerber AN. (2015) Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops. J Biol Chem. 290(32):19756-69. DOI: 10.1074/jbc.M115.668558. PMID: 26088140

Pufall MA. (2015) Glucocorticoids and Cancer. Adv Exp Med Biol. 872:315-33. DOI: 10.1007/978-1-4939-2895-8_14. PMID: 26216001

Peter A. Rubenstein

Rubenstein PA, Wen KK. (2015) Mutant vascular actin is a TAAD misbehaving. Proc Natl Acad Sci USA. 112(31):9500-1. DOI: 10.1073/pnas.1512086112. PMID: 26204915

Michael J. Schnieders

Bu F, Borsa NG, Jones MB, Takanami E, Nishimura C, Hauer JJ, Azaiez H, Black-Ziegelbein EA, Meyer NC, Kolbe DL, Li Y, Frees K, Schnieders MJ, Thomas C, Nester C, Smith RJ. 92015) High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies. J Am Soc Nephrol. pii: ASN.2015040385. PMID:26283675

LuCore SD, Litman JM, Powers KT, Gao S, Lynn AM, Tollefson WT, Fenn TD, Washington MT, Schnieders MJ. (2015) Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures. Biophys J. 109(4):816-26. DOI: 10.1016/j.bpj.2015.06.062. PMID: 26287633

Booth KT, Azaiez H, Kahrizi K, Simpson AC, Tollefson WT, Sloan CM, Meyer NC, Babanejad M, Ardalani F, Arzhangi S, Schnieders MJ, Najmabadi H, Smith RJ. (2015) PDZD7 and hearing loss: More than just a modifier. Am J Med Genet A. 167(12):2957-65. DOI: 10.1002/ajmg.a.37274. PMID: 26416264

DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC. (2015) Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. Hum Mol Genet. 25(1):44-56. DOI: 10.1093/hmg/ddv446. PMID: 26494905

Lagardère L, Lipparini F, Stamm B, Schnieders MJ, Cances E, Ren P, Maday Y, Piquemal J. (2015) Scalable Evaluation of Polarization Energy and Associated Forces in Polarizable Molecular Dynamics: II. Towards Massively Parallel Computations Using Smooth Particle Mesh Ewald. Journal of Chemical Theory and Computation. 11(6):2589–2599.

Debra A. Schwinn

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM. (2015) Research in academic medical centers: two threats to sustainable support. Sci Transl Med. 7(289):289fs22. DOI: 10.1126/scitranslmed.aac5200. PMID: 26019216

Morris DP, Lei B, Longo LD, Bomsztyk K, Schwinn DA, Michelotti GA. (2015) Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation. PLoS One. 10(8):e0134442. DOI: 10.1371/journal.pone.0134442. PMID: 26244980

Gradinaru I, Babaeva E, Schwinn DA, Oganesian A. (2015) Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway. PLoS One. 10(11):e0142787. DOI: 10.1371/journal.pone.0142787. PMID: 26571308

Madeline A. Shea

Feldkamp MD, Gakhar L, Pandey N, Shea MA. (2015) Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin. Proteins. 83(5):989-96. DOI: 10.1002/prot.24781. PMID: 25694384

M. Ashley Spies

Dean SF, Whalen KL, Spies MA. (2015) Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level. ACS Cent Sci. 1(7):364-373. PMID: 26539562

Marsden AE, King JM, Spies MA, Kim OK, Yahr TL. (2015) Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N-Hydroxybenzimidazoles. Antimicrob Agents Chemother. 60(2):766-76. DOI: 10.1128/AAC.02242-15. PMID: 26574012

Maria Spies

Spies M, Fishel R. (2015) Mismatch repair during homologous and homeologous recombination. Cold Spring Harb Perspect Biol. 7(3):a022657. DOI: 10.1101/cshperspect.a022657. PMID: 25731766

Earle Stellwagen

Stellwagen E, Dong Q, Stellwagen NC. (2015) Flanking A·T basepairs destabilize the B(∗) conformation of DNA A-tracts. Biophys J. 108(9):2291-9. DOI: 10.1016/j.bpj.2015.01.044. PMID: 25954886

Stellwagen E, Stellwagen NC. (2015) Electrostatic coupling between DNA and its counterions modulates the observed translational diffusion coefficients. Anal Chem. 87(17):9042-6. DOI: 10.1021/acs.analchem.5b02230. PMID: 26218420

Nancy C. Stellwagen

Stellwagen E, Dong Q, Stellwagen NC. (2015) Flanking A·T basepairs destabilize the B(∗) conformation of DNA A-tracts. Biophys J. 108(9):2291-9. DOI: 10.1016/j.bpj.2015.01.044. PMID: 25954886

Stellwagen E, Stellwagen NC. (2015) Electrostatic coupling between DNA and its counterions modulates the observed translational diffusion coefficients. Anal Chem. 87(17):9042-6. DOI: 10.1021/acs.analchem.5b02230. PMID: 26218420

Eric B. Taylor

Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB. (2015) Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell Metab. 22(4):669-81. DOI: 10.1016/j.cmet.2015.07.027. PMID: 26344103

Lori L. Wallrath

Bohnekamp J, Cryderman DE, Paululat A, Baccam GC, Wallrath LL, Magin TM. (2015) A Drosophila Model of Epidermolysis Bullosa Simplex. J Invest Dermatol. 135(8):2031-9. DOI: 10.1038/jid.2015.129. PMID: 25830653

Dialynas G, Shrestha OK, Ponce JM, Zwerger M, Thiemann DA, Young GH, Moore SA, Yu L, Lammerding J, Wallrath LL. (2015) Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. PLoS Genet. 11(5):e1005231. DOI: 10.1371/journal.pgen.1005231. PMID: 25996830

Bohnekamp J, Cryderman DE, Thiemann DA, Magin TM, Wallrath LL. (2015) Using Drosophila for Studies of Intermediate Filaments. Methods Enzymol. 568:707-26. DOI: 10.1016/bs.mie.2015.08.028. PMID: 26795490

M. Todd Washington

Tsutakawa SE, Yan C, Xu X, Weinacht CP, Freudenthal BD, Yang K, Zhuang Z, Washington MT, Tainer JA, Ivanov I. (2015) Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response. Structure. 23(4):724-33. DOI: 10.1016/j.str.2015.02.008. PMID: 25773143

LuCore SD, Litman JM, Powers KT, Gao S, Lynn AM, Tollefson WT, Fenn TD, Washington MT, Schnieders MJ. (2015) Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures. Biophys J. 109(4):816-26. DOI: 10.1016/j.bpj.2015.06.062. PMID: 26287633

Ronald J. Weigel

Borcherding N, Kusner D, Kolb R, Xie Q, Li W, Yuan F, Velez G, Askeland R, Weigel RJ, Zhang W. (2015) Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells. Cancer Res. 75(10):1972-82. DOI: 10.1158/0008-5472.CAN-14-2761. PMID: 25769722

Lizarraga I, Schroeder MC, Weigel RJ, Thomas A. (2015) Surgical Management of Breast Cancer in 2010-2011 SEER Registries by Hormone and HER2 Receptor Status. Ann Surg Oncol. 22 Suppl 3:566-72. DOI: 10.1245/s10434-015-4591-3. PMID: 25956579

Spanheimer PM, Lorenzen AW, De Andrade JP, Kulak MV, Carr JC, Woodfield GW, Sugg SL, Weigel RJ. (2015) Receptor Tyrosine Kinase Expression Predicts Response to Sunitinib in Breast Cancer. Ann Surg Oncol. 22(13):4287-94. DOI: 10.1245/s10434-015-4597-x. PMID: 25971960

Weigel RJ. (2015) 2015 Presidential Address–Society of Surgical Oncology: The Next 75 Years. Ann Surg Oncol. 22(8):2455-61. DOI: 10.1245/s10434-015-4638-5. PMID: 26033181

Weigel RJ, Upchurch GR Jr, Eberlein TJ, Lucas CE. (2015) Presidential Forum Discussion: Development of Surgical Scientists. Ann Surg. 262(4):555-62. DOI: 10.1097/SLA.0000000000001400. PMID: 26366534

Lizarraga IM, Weigel RJ. (2015) Axillary lymph node dissection for breast cancer: Primum non nocere. Eur J Surg Oncol. 41(8):955-7. DOI: 10.1016/j.ejso.2015.05.006. PMID: 26071786

Meng Wu

Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161(6):1252-65. DOI: 10.1016/j.cell.2015.05.023. PMID: 26046436

Wongrakpanich A, Wu M, Salem AK. (2015) Correlating intracellular nonviral polyplex localization with transfection efficiency using high-content screening. Biotechnol Prog. 31(6):1685-92. DOI: 10.1002/btpr.2146. PMID: 26193826

Wu M, Li M. (2015) Resonant waveguide grating for monitoring biomolecular interactions. Methods Mol Biol. 1278:139-52. DOI: 10.1007/978-1-4939-2425-7_8. PMID: 25859947

Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakur DP, Zhu J, Deng Z, Hu X, Wu M, McManus OB, Li M, Hong X, Zhu MX, Luo HR. (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 172(14):3495-509. DOI: 10.1111/bph.13140. PMID: 25816897

Li J, Crowley ST, Duskey J, Khargharia S, Wu M, Rice KG. (2015) Miniaturization of gene transfection assays in 384- and 1536-well microplates. Anal Biochem. 470:14-21. DOI: 10.1016/j.ab.2014.10.001. PMID: 25448623

Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD. (2015) Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem Neurosci. 6(3):417-27. DOI: 10.1021/cn5001809. PMID: 25560927

Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR. (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem. 10(1):57-61. DOI: 10.1002/cmdc.201402277. PMID: 25209672

Liping Yu

Yu L, Fink BD, Sivitz WI. (2015) Simultaneous quantification of mitochondrial ATP and ROS production. Methods Mol Biol. 1264:149-59. DOI: 10.1007/978-1-4939-2257-4_14. PMID: 25631011

Dialynas G, Shrestha OK, Ponce JM, Zwerger M, Thiemann DA, Young GH, Moore SA, Yu L, Lammerding J, Wallrath LL. (2015) Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. PLoS Genet. 11(5):e1005231.DOI: 10.1371/journal.pgen.1005231. PMID: 25996830

Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. (2015) Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci USA. 112(29):9129-34. DOI: 10.1073/pnas.1504705112. PMID: 26153425

 

Geyer elected Fellow of the American Association for the Advancement of Science

Wednesday, November 25th, 2015

_D3A3837_geyerDr. Pamela Geyer has been elected as a Fellow of the American Association for the Advancement of Science (AAAS) “distinguished contributions to the field of eukaryotic transcription, particularly founding discoveries of the insulator class of regulatory elements and mechanisms of tissue-specific gene expression.” Among current Biochemistry primary faculty, Dr. Geyer joins Drs. Marc Wold, Charles Brenner, David Price, and Peter Rubenstein as AAAS fellows.

2015 Biochemistry Newsletter now available

Tuesday, October 20th, 2015

Cover_2015_newsletterThe 2015 Biochemistry @ Iowa newsletter is hot off the presses and available for download. Alumni and friends should receive a hard copy in the mail this week. If you would like to be added to our mailing list, please send your contact information to biochem@uiowa.edu. While you are at it, feel free to send us your news and updates! Previous newsletters are also available online.

Lacy Barton receives 2015 Subramanian Thesis Award

Thursday, September 24th, 2015

Lacy Barton, who completed her PhD with Dr. Pamela Geyer, has been named the 2015 Subramanian Award for best PhD thesis in the Department of Biochemistry. Lacy is currently a postdoctoral fellow in Ruth Lehmann’s laboratory at New York University School of Medicine in New York, NY. She was recently awarded a Damon Runyon Cancer Research Foundation Fellowship for her project entitled “Mechanisms of directed cell migration in a complex in vivo environment.” Damon Runyon fellowships are among the most recognized postdoctoral awards and a high accolade for an early career scientist.

Lacy  is the 22nd winner of the Subramanian Award, which is made possible by a gift from Dr. Alap Subramanian, a 1964 PhD from the department, who parlayed his training with the late George Kalnitsky, (and with Irving Klotz at Northwestern and both Bernard Davis and Herman Kalckar at Harvard Medical School), into a highly successful career at the Max-Planck-Institut. Our deepest thanks to Dr. Subramanian and our heartiest congratulations to Dr. Barton.

Please visit our website for a complete list of previous winners of the Subramanian Award.

2014 Publications

Monday, February 16th, 2015

The Department’s 2014 publications are now in print and mostly available online.

E. Dale Abel

Riehle C, Abel ED. (2014) Insulin regulation of myocardial autophagy. Circ J. 78(11):2569-76. PMID: 25327953

Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED. (2014) GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure. J Mol Cell Cardiol. 72:95-103. DOI: 10.1016/j.yjmcc.2014.02.011. PMID: 24583251

Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. (2014) Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol. 34(18):3450-60. DOI: 10.1128/MCB.00426-14. PMID: 25002528

Wende AR, O’Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. (2014) Enhanced Cardiac Akt/PKB Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function Via Transcriptional Repression of Nuclear-Encoded Mitochondrial Genes. Mol Cell Biol. 35(5):831-46. DOI: 10.1128/MCB.01109-14. PMID: 25535334

Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED. (2014) Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. FASEB J. 28(8):3691-702. DOI: 10.1096/fj.14-253823. PMID: 24776744

Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. (2014) Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 63(8):2676-89. DOI: 10.2337/db13-1763. PMID: 24677713

Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. (2014) Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circ Heart Fail. 7(1):184-93. DOI: 10.1161/CIRCHEARTFAILURE.113.000649. PMID: 24319095

Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. (2014) Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes. 63(1):75-88. DOI: 10.2337/db13-0340. PMID: 24009260

Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M. (2014) The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol. 306(5):H747-54. DOI: 10.1152/ajpheart.00849.2013. PMID: 24375641

Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. (2014) Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 192(8):3626-36. DOI: 10.4049/jimmunol.1302062. PMID: 24616478

Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. (2014) The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 20(1):61-72. DOI: 10.1016/j.cmet.2014.05.004. PMID: 24930970

Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC. (2014) Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. Cell Death Dis. 5:e1470. DOI: 10.1038/cddis.2014.431. PMID: 25321477

Sheila A. Baker

Pan Y, Laird JG, Yamaguchi DM, Baker SA. (2014) A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane. Cell Mol Life Sci. PMID: 25142030

Pearring JN, Lieu EC, Winter JR, Baker SA, Arshavsky VY. (2014) R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. Mol Biol Cell. 25(17):2644-9. DOI: 10.1091/mbc.E14-02-0747. PMID: 25009288

Pan Y, Bhattarai S, Modestou M, Drack AV, Chetkovich DM, Baker SA. (2014) TRIP8b is required for maximal expression of HCN1 in the mouse retina. PLoS One. 9(1):e85850. DOI: 10.1371/journal.pone.0085850. PMID: 24409334

Heather L. Bartlett

Pierick AR, McKane M, Wen KK, Bartlett HL. (2014) Aip1p dynamics are altered by the R256H mutation in actin. J Vis Exp. (89):e51551. DOI: 10.3791/51551. PMID: 25146730

Charles M. Brenner

Brenner C. Boosting NAD to Spare Hearing. Cell Metab. 20(6):926-7. DOI: 10.1016/j.cmet.2014.11.015. PMID: 25470539

Wu BK, Brenner C. Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation. Cell Rep. 9(5):1827-40. DOI: 10.1016/j.celrep.2014.10.063. PMID: 25466250

Mei SC, Brenner C. (2014) Quantification of protein copy number in yeast: the NAD+ metabolome. PLoS One. 9(9):e106496. DOI: 10.1371/journal.pone.0106496. PMID: 25188219

Wu BK, Mei SC, Brenner C. (2014) RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation. Cell Cycle. 13(20):3222-31. DOI: 10.4161/15384101.2014.950886. PMID: 25485502

Boylston JA, Brenner C. (2014) A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1. Cell Cycle. 13(18):2913-30. DOI: 10.4161/15384101.2014.946858. PMID: 25486479

Brenner C. (2014) Histidine Triad Superfamily. Encyclopedia of Life Sciences, John Wiley & Sons Ltd: Chichester.  DOI: 10.1002/9780470015902.a0020545.pub2.

Brenner C. (2014) Metabolism: Targeting a fat-accumulation gene. Nature. 508(7495):194-5. DOI: 10.1038/508194a. PMID: 24717510

Brenner C. (2014) Understanding Faculty Salaries. ASBMB Today, 3(1):28-29.

Huang J, Stewart A, Maity B, Hagen J, Fagan RL, Yang J, Quelle DE, Brenner C, Fisher RA. (2014) RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis. Oncogene. 33(27):3604-11. DOI: 10.1038/onc.2013.324. PMID: 23995786

John M. Dagle

Fuller TD, Spracklen CN, Ryckman KK, Knake LA, Busch TD, Momany AM, Murray JC, Dagle JM. (2014) Genetic Variation in CYB5R3 is Associated with Methemoglobin Levels in Preterm Infants Receiving Nitric Oxide Therapy. Pediatr Res. DOI: 10.1038/pr.2014.206. PMID: 25521918

Sampath V, Garland JS, Helbling D, Dimmock D, Mulrooney NP, Simpson PM, Murray JC, Dagle JM. (2014) Anti-Oxidant Response Genes sequence variants and BPD susceptibility in VLBW infants. Pediatr Res. DOI: 10.1038/pr.2014.200. PMID: 25518008

Naderi HM, Murray JC, Dagle JM. (2014) Single mutations in ABCA3 increase the risk for neonatal respiratory distress syndrome in late preterm infants (gestational age 34-36 weeks). Am J Med Genet A. 164A(10):2676-8. DOI: 10.1002/ajmg.a.36660. PMID: 25073622

Ryckman KK, Spracklen CN, Dagle JM, Murray JC. (2014) Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone. J Pediatr Endocrinol Metab. 27(9-10):929-38. DOI: 10.1515/jpem-2013-0366. PMID: 24854527

Hartnett ME, Morrison MA, Smith S, Yanovitch TL, Young TL, Colaizy T, Momany A, Dagle J, Carlo WA, Clark EA, Page G, Murray J, DeAngelis MM, Cotten CM; Genomics Subcommittee. (2014) Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. Invest Ophthalmol Vis Sci. 55(10):6194-203. DOI: 10.1167/iovs.14-14841.PMID: 25118269

Kris A. DeMali

Mahauad-Fernandez WD, DeMali KA, Olivier AK, Okeoma CM. (2014) Bone marrow stromal antigen 2 expressed in cancer cells promotes mammary tumor growth and metastasis. Breast Cancer Res. 16(6):493. PMID: 25499888

DeMali KA, Sun X, Bui GA. (2014) Force transmission at cell-cell and cell-matrix adhesions. Biochemistry. 53(49):7706-17. DOI: 10.1021/bi501181p. PMID: 25474123

Biggs LC, Naridze RL, DeMali KA, Lusche DF, Kuhl S, Soll DR, Schutte BC, Dunnwald M. (2014) Interferon regulatory factor 6 regulates keratinocyte migration. J Cell Sci. 127(Pt 13):2840-8. DOI: 10.1242/jcs.139246. PMID: 24777480

Bays JL, Peng X, Tolbert CE, Guilluy C, Angell AE, Pan Y, Superfine R, Burridge K, DeMali KA. (2014) Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol. 205(2):251-63. DOI: 10.1083/jcb.201309092. PMID: 24751539

Adrian H. Elcock

Andrews CT, Elcock AH. (2014) COFFDROP: A Coarse-Grained Nonbonded Force Field for Proteins Derived from All-Atom Explicit-Solvent Molecular Dynamics Simulations of Amino Acids. J Chem Theory Comput. 10(11):5178-5194. PMID: 25400526

Theillet FX, Binolfi A, Frembgen-Kesner T, Hingorani K, Sarkar M, Kyne C, Li C, Crowley PB, Gierasch L, Pielak GJ, Elcock AH, Gershenson A, Selenko P. (2014) Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 114(13):6661-714. DOI: 10.1021/cr400695p. PMID: 24901537

Azzaz AM, Vitalini MW, Thomas AS, Price JP, Blacketer MJ, Cryderman DE, Zirbel LN, Woodcock CL, Elcock AH, Wallrath LL, Shogren-Knaak MA. (2014) Human heterochromatin protein 1α promotes nucleosome associations that drive chromatin condensation. J Biol Chem. 289(10):6850-61. DOI: 10.1074/jbc.M113.512137. PMID: 24415761

Ernesto J. Fuentes

Darnell CL, Wilson JM, Tiwari N, Fuentes EJ, Kirby JR. (2014) Chemosensory regulation of a HEAT-repeat protein couples aggregation and sporulation in Myxococcus xanthus. J Bacteriol. 196(17):3160-8. DOI: 10.1128/JB.01866-14. PMID: 24957622

Lokesh Gakhar

Cheguru P, Majumder A, Yadav R, Gopalakrishna KN, Gakhar L, Artemyev NO. (2014) The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ1 γ1 -binding sites. FEBS J. 282(3):550-61. DOI: 10.1111/febs.13161. PMID: 25425538

Streeter J, Schickling BM, Jiang S, Stanic B, Thiel WH, Gakhar L, Houtman JC, Miller FJ Jr. (2014) Phosphorylation of Nox1 regulates association with NoxA1 activation domain. Circ Res. 115(11):911-8. DOI: 10.1161/CIRCRESAHA.115.304267. PMID: 25228390

Ver Heul AM, Gakhar L, Piper RC, Subramanian R. (2014) Crystal structure of a complex of NOD1 CARD and ubiquitin. PLoS One. 9(8):e104017. DOI: 10.1371/journal.pone.0104017. PMID: 25127239

Doron D, Stojković V, Gakhar L, Vardi-Kilshtain A, Kohen A, Major DT. (2014) Free Energy Simulations of Active-Site Mutants of Dihydrofolate Reductase. J Phys Chem B. 119(3):906-16. DOI: 10.1021/jp5059963.PMID: 25382260

Pamela K. Geyer

Barton LJ, Wilmington SR, Martin MJ, Skopec HM, Lovander KE, Pinto BS, Geyer PK. (2014) Unique and shared functions of nuclear lamina LEM domain proteins in Drosophila. Genetics. 197(2):653-65. DOI: 10.1534/genetics.114.162941. PMID: 24700158

Theresa L. Gioannini

Gioannini TL, Teghanemt A, Zhang D, Esparza G, Yu L, Weiss J. (2014) Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins. Immunol Res. 59(1-3):3-11. DOI: 10.1007/s12026-014-8543-y. PMID: 24895101

Resman N, Oblak A, Gioannini TL, Weiss JP, Jerala R. (2014) Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions. J Immunol. 192(4):1887-95. DOI: 10.4049/jimmunol.1302119. PMID: 24420921

Catherine A. Musselman

Wang C, Chen Z, Hong X, Ning F, Liu H, Zang J, Yan X, Kemp J, Musselman CA, Kutateladze TG, Zhao R, Jiang C, Zhang G. (2014) The structural basis of urea-induced protein unfolding in β-catenin. Acta Crystallogr D Biol Crystallogr. 70(Pt 11):2840-7. DOI: 10.1107/S1399004714018094. PMID: 25372676

Ezhov RN, Metzel GA, Mukhina OA, Musselman CA, Kutateladze TG, Gustafson TP, Kutateladze AG. (2014) Photoactive Spatial Proximity Probes for Binding Pairs with Epigenetic Marks. J Photochem Photobiol A Chem. 290:101-108. PMID: 25197204

Musselman CA, Khorasanizadeh S, Kutateladze TG. (2014) Towards understanding methyllysine readout. Biochim Biophys Acta. 1839(8):686-93. DOI: 10.1016/j.bbagrm.2014.04.001. PMID: 24727128

Allen HF, Daze KD, Shimbo T, Lai A, Musselman CA, Sims JK, Wade PA, Hof F, Kutateladze TG.(2014) Inhibition of histone binding by supramolecular hosts. Biochem J. 459(3):505-12. DOI: 10.1042/BJ20140145. PMID: 24576085

Andrew W. Norris

Mark AL, Norris AW, Rahmouni K. (2014) Sympathetic inhibition after bariatric surgery. Hypertension. 64(2):235-6. DOI: 10.1161/HYPERTENSIONAHA.114.03183. PMID: 24866141

Baack ML, Wang C, Hu S, Segar JL, Norris AW. (2014) Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: an in vivo test of the fuel mediated teratogenesis hypothesis. Reprod Toxicol. 46:129-36. DOI: 10.1016/j.reprotox.2014.03.013. PMID: 24721120

Norris AW, Bahr TM, Scholz TD, Peterson ES, Volk KA, Segar JL. (2014) Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep. Pediatr Res. 75(6):689-96. DOI: 10.1038/pr.2014.37. PMID: 24614802

Sui H, Yi Y, Yao J, Liang B, Sun X, Hu S, Uc A, Nelson DJ, Ode KL, Philipson LH, Engelhardt JF, Norris AW. (2014) Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets. PLoS One. 9(3):e90519. DOI: 10.1371/journal.pone.0090519. PMID: 24594704

Bryce V. Plapp

Baskar Raj S, Ramaswamy S, Plapp BV. (2014) Yeast alcohol dehydrogenase structure and catalysis. Biochemistry. 53(36):5791-803. DOI: 10.1021/bi5006442. PMID: 25157460

Yahashiri A, Rubach JK, Plapp BV. (2014) Effects of cavities at the nicotinamide binding site of liver alcohol dehydrogenase on structure, dynamics and catalysis. Biochemistry. 53(5):881-94. DOI: 10.1021/bi401583f. PMID: 24437493

David H. Price

Guo J, Li T, Schipper J, Nilson KA, Fordjour FK, Cooper JJ, Gordân R, Price DH. (2014) Sequence specificity incompletely defines the genome-wide occupancy of Myc. Genome Biol. 15(10):482. PMID: 25287278

Gu J, Babayeva ND, Suwa Y, Baranovskiy AG, Price DH, Tahirov TH. (2014) Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle. 13(11):1788-97. DOI: 10.4161/cc.28756. PMID: 24727379

Guo J, Turek ME, Price DH. (2014) Regulation of RNA polymerase II termination by phosphorylation of Gdown1. J Biol Chem. 289(18):12657-65. DOI: 10.1074/jbc.M113.537662. PMID: 24634214

Mullen Davis MA, Guo J, Price DH, Luse DS. (2014) Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF. J Biol Chem. 289(16):11143-52. DOI: 10.1074/jbc.M113.544395. PMID: 24596085

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM. (2014) Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription. J Biol Chem. 289(14):9918-25. DOI: 10.1074/jbc.M113.539015. PMID: 24515107

Fowler T, Ghatak P, Price DH, Conaway R, Conaway J, Chiang CM, Bradner JE, Shilatifard A, Roy AL. (2014) Regulation of MYC expression and differential JQ1 sensitivity in cancer cells. PLoS One. 9(1):e87003. DOI: 10.1371/journal.pone.0087003. PMID: 24466310

Miles A. Pufall

Bongers KS, Fox DK, Kunkel SD, Stebounova LV, Murry DJ, Pufall MA, Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Adams CM. (2014) Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy. Am J Physiol Endocrinol Metab. 308(2):E144-58. DOI: 10.1152/ajpendo.00472.2014. PMID: 25406264

Peter A. Rubenstein

Bai F, Caster HM, Rubenstein PA, Dawson JF, Kawai M. (2014) Using baculovirus/insect cell expressed recombinant actin to study the molecular pathogenesis of HCM caused by actin mutation A331P. J Mol Cell Cardiol. 74:64-75. DOI: 10.1016/j.yjmcc.2014.04.014. PMID: 24793351

Yamashiro S, Gokhin DS, Sui Z, Bergeron SE, Rubenstein PA, Fowler VM. (2014) Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms. J Biol Chem. 289(17):11616-29. DOI: 10.1074/jbc.M114.555128. PMID: 24644292

Rubenstein PA, Wen KK. (2014) Insights into the effects of disease-causing mutations in human actins. Cytoskeleton (Hoboken). 71(4):211-29. DOI: 10.1002/cm.21169. PMID: 24574087

Michael J. Schnieders

Park J, Nessler I, McClain B, Macikenas D, Baltrusaitis J, Schnieders MJ. (2014) Absolute Organic Crystal Thermodynamics: Growth of the Asymmetric Unit into a Crystal via Alchemy. J. Chem. Theory Comput. 10 (7): 2781-2791.

Lipparini F, Lagardère L, Stamm B, Cancès E, Schnieders MJ, Ren P, Maday Y, Piquemal J-P. (2014) Scalable Evaluation of Polarization Energy and Associated Forces in Polarizable Molecular Dynamics: I. Toward Massively Parallel Direct Space Computations. J. Chem. Theory Comput. 10 (4): 1638-1651.

Debra A. Schwinn

Schwinn DA. (2014) Team-based patient care. Learning the delicate dance. Iowa Med. 104(3):19. PMID: 25174086

Schwinn DA. (2014) Unlocking the great GME bottleneck. Iowa Med. 104(1):22. PMID: 25167620

Shields RK, Pizzimenti MA, Dudley-Javoroski S, Schwinn DA. (2014) Fostering interprofessional teamwork in an academic medical center: Near-peer education for students during gross medical anatomy. Anat Sci Educ. DOI: 10.1002/ase.1466. PMID: 24888728

Kleine-Brueggeney M, Gradinaru I, Babaeva E, Schwinn DA, Oganesian A. (2014) Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways. Cell Signal. 26(9):1985-97. DOI: 10.1016/j.cellsig.2014.05.007. PMID: 24835978

Madeline A. Shea

Newman RA, Sorensen BR, Kilpatrick AM, Shea MA. (2014) Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1). Biophys Chem. 193-194:35-49. DOI: 10.1016/j.bpc.2014.07.004. PMID: 25145833

Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH. (2014) Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. Sci Signal. 7(337):ra74. DOI: 10.1126/scisignal.2005147. PMID: 25097034

Maria Spies

Ghoneim M, Spies M. (2014) Direct correlation of DNA binding and single protein domain motion via dual illumination fluorescence microscopy. Nano Lett. 14(10):5920-31. DOI: 10.1021/nl502890g. PMID: 25204359

Spies M. (2014) Fulfilling the dream of a perfect genome editing tool. Proc Natl Acad Sci U S A. 111(28):10029-30. DOI: 10.1073/pnas.1408985111. PMID: 24989506

Spies M. (2014) Two steps forward, one step back: determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers. DNA Repair (Amst). 20:58-70. DOI: 10.1016/j.dnarep.2014.01.013. PMID: 24560558

Honda M, Okuno Y, Hengel SR, Martín-López JV, Cook CP, Amunugama R, Soukup RJ, Subramanyam S, Fishel R, Spies M. (2014) Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate. Proc Natl Acad Sci U S A. 111(3):E316-25. DOI: 10.1073/pnas.1312988111. PMID: 24395779

Earle Stellwagen

Stellwagen NC, Peters JP, Dong Q, Maher LJ 3rd, Stellwagen E. (2014) The free solution mobility of DNA and other analytes varies as the logarithm of the fractional negative charge. Electrophoresis. 35(12-13):1855-63. DOI: 10.1002/elps.201400040. PMID: 24648187

Nancy C. Stellwagen

Stellwagen NC, Peters JP, Dong Q, Maher LJ 3rd, Stellwagen E. (2014) The free solution mobility of DNA and other analytes varies as the logarithm of the fractional negative charge. Electrophoresis. 35(12-13):1855-63. DOI: 10.1002/elps.201400040. PMID: 24648187

Eric B. Taylor

Gray LR, Tompkins SC, Taylor EB. (2014) Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. 71(14):2577-604. DOI: 10.1007/s00018-013-1539-2. PMID: 24363178

Lori L. Wallrath

Wallrath LL, Vitalini MW, Elgin SCR. (2014) Heterochromatin: A Critical Part of the Genome. Fundamentals of Chromatin. 529-552.

Azzaz AM, Vitalini MW, Thomas AS, Price JP, Blacketer MJ, Cryderman DE, Zirbel LN, Woodcock CL, Elcock AH, Wallrath LL, Shogren-Knaak MA. (2014) Human heterochromatin protein 1α promotes nucleosome associations that drive chromatin condensation. J Biol Chem. 289(10):6850-61. DOI: 10.1074/jbc.M113.512137. PMID: 24415761

M. Todd Washington

Pryor JM, Dieckman LM, Boehm EM, Washington TM. (2014) Eukaryotic Y-Family Polymerases: A Biochemical and Structural Perspective. Nucleic Acid Polymerases: Nucleic Acids and Molecular Biology. 30: 5-10.

Ronald J. Weigel

Bogachek MV, De Andrade JP, Weigel RJ. (2014) Regulation of Epithelial-Mesenchymal Transition through SUMOylation of Transcription Factors. Cancer Res. 75(1):11-15. PMID: 25524900

Bogachek MV, Park JM, De Andrade JP, Kulak MV, White JR, Wu T, Spanheimer PM, Bair TB, Olivier AK, Weigel RJ. (2014) A Novel Animal Model for Locally Advanced Breast Cancer. Ann Surg Oncol. PMID: 25326397

Xia C, Schroeder MC, Weigel RJ, Sugg SL, Thomas A. (2014) Rate of contralateral prophylactic mastectomy is influenced by preoperative MRI recommendations. Ann Surg Oncol. 21(13):4133-8. DOI: 10.1245/s10434-014-3852-x. PMID: 24934585

Bogachek MV, Chen Y, Kulak MV, Woodfield GW, Cyr AR, Park JM, Spanheimer PM, Li Y, Li T, Weigel RJ. (2014) Sumoylation pathway is required to maintain the basal breast cancer subtype. Cancer Cell. 25(6):748-61. DOI: 10.1016/j.ccr.2014.04.008. PMID: 24835590

Spanheimer PM, Park JM, Askeland RW, Kulak MV, Woodfield GW, De Andrade JP, Cyr AR, Sugg SL, Thomas A, Weigel RJ. (2014) Inhibition of RET increases the efficacy of antiestrogen and is a novel treatment strategy for luminal breast cancer. Clin Cancer Res. 20(8):2115-25. DOI: 10.1158/1078-0432.CCR-13-2221. PMID: 24526731

Cyr AR, Kulak MV, Park JM, Bogachek MV, Spanheimer PM, Woodfield GW, White-Baer LS, O’Malley YQ, Sugg SL, Olivier AK, Zhang W, Domann FE, Weigel RJ. (2014) TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene. 34(4):436-44. DOI: 10.1038/onc.2013.569. PMID: 24469049

Marc S. Wold

Chen R, Wold MS. (2014) Replication protein A: single-stranded DNA’s first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair. Bioessays. 36(12):1156-61. DOI: 10.1002/bies.201400107. PMID: 25171654

Nguyen B, Sokoloski J, Galletto R, Elson EL, Wold MS, Lohman TM. (2014) Diffusion of human replication protein A along single-stranded DNA. J Mol Biol. 426(19):3246-61. DOI: 10.1016/j.jmb.2014.07.014. PMID: 25058683

Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M, Brosh RM Jr. (2014) Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner. J Biol Chem. 289(29):19928-41. DOI: 10.1074/jbc.M113.542456. PMID: 24895130

Meng Wu

Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR. (2014) Discovery and Characterization of 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1. ChemMedChem. 10(1):57-61. DOI: 10.1002/cmdc.201402277. PMID: 25209672

Flaherty DP, Simpson DS, Miller M, Maki BE, Zou B, Shi J, Wu M, McManus OB, Aubé J, Li M, Golden JE. (2014) Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett. 24(16):3968-73. DOI: 10.1016/j.bmcl.2014.06.032. PMID: 25017033

Liping Yu

Willer T, Inamori K, Venzke D, Harvey C, Morgensen G, Hara Y, Beltrán Valero de Bernabé D, Yu L, Wright KM, Campbell KP. (2014) The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. Elife. 3. DOI: 10.7554/eLife.03941. PMID: 25279699

Gioannini TL, Teghanemt A, Zhang D, Esparza G, Yu L, Weiss J. (2014) Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins. Immunol Res. 59(1-3):3-11. DOI: 10.1007/s12026-014-8543-y. PMID: 24895101

Yu L, Fink BD, Herlein JA, Oltman CL, Lamping KG, Sivitz WI. (2014) Dietary fat, fatty acid saturation and mitochondrial bioenergetics. J Bioenerg Biomembr. 46(1):33-44. PMID: 24121995

Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI. (2014) A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice. J Pharmacol Exp Ther. 351(3):699-708. DOI: 10.1124/jpet.114.219329. PMID: 25301169

Professor Geyer receives the CCOM Collegiate Teaching Award

Friday, December 12th, 2014

Congratulations to Professor Pamela Geyer for being chosen to receive a Carver College of Medicine Collegiate Teaching Award for 2014. Professor Geyer has demonstrated excellence in teaching for the past two and a half decades at the University of Iowa. The superb ratings and comments from students are a testament of her skill as an instructor. Professor Geyer has had an enormous impact on graduate education at the University of Iowa, chairing a task force that re-shaped the graduate curriculum that is in place today.

Among current Biochemistry primary faculty, Dr. Geyer joins Drs. Peter Rubenstein, Adrian Elcock, Lori Wallrath, Dan Weeks, Todd Washington, and Kris DeMali recipients of the CCOM Collegiate Teaching Award. This is the 5th consecutive year a Biochemistry faculty member has received this award.