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Archive for the ‘Carl Vestling’ Category
Dr. Jay C. Dunlap delivered this year’s Vestling Lecture, entitled “Genetic and Molecular Dissection of a Simple Circadian System.” Jay is the Nathan Smith Chair of genetics at Dartmouth, a member of the National Academy of Sciences, and the recipient of the George Beadle Medal from the Genetics Society of America. His laboratory, jointly run with Dr. Jennifer Loros, has made fundamental contributions to the molecular dissection of circadian function. Their discoveries include broad-ranging contributions to transcriptional regulation of rhythm; definition of feedback loops that are regulated by light, temperature and post-translational processing; characterization of roles of anti-sense RNA, alternative splicing, chromatin remodeling, the cell cycle, and protein stability in circadian regulation; and the functional genomics of Neurospora.
Vestling and Dunlap both started their independent careers with spectroscopic studies of small molecules before turning their attention to more complex problems. In Dr. Vestling’s case, the small molecule was porphyrin. He later developed a research program on some of the most classic enzymes, such as fructokinase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase. In addition to his influential work on characterization of lactate dehydrogenase, he established methods to determine dissociation constants of two-substrate enzyme systems and helped build the legacy of biochemistry at Iowa. Dr. Dunlap’s graduate project, before he took on circadian function, involved using spectroscopy to determine the structure of Dinoflagellate luciferin.
Dr. Dunlap’s lecture was jointly sponsored by the Carver College of Medicine Distinguished Biomedical Scholars Lecture Series. After the lecture, the Department hosted a reception to reopen the newly remodeled Heath Conference Room.
Dr. David Allis, the Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology at Rockefeller University will deliver this year’s Vestling Lecture in the Sahai Auditorium at 4 pm on February 25. The title of Allis’s lecture is “Beyond the Double Helix: Reading & Writing the Histone Code.” A reception will follow the lecture. (more…)