Link: University of Iowa

Article by Ran Chen and Marc Wold Featured on the Cover of BioEssays

Graduate student Ran Chen (Wold Lab) and Biochemistry Professor Marc Wold recently published an article that was featured on the cover of BioEssays (volume 35, issue 12). The article, entitled “Replication protein A: Single-stranded DNA’s first responder”, reviews recent discoveries from the Wold and other labs that show that replication protein A (RPA), the major eukaryotic single-stranded DNA-binding protein, binds DNA dynamically. It also proposes a new model for RPA binding and discusses the importance of dynamic binding in the correct processing of single-stranded DNA intermediates and genome stability.


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