Dr. Maria Spies laboratory recently published an Proceedings of National Academy of Sciences article entitled “Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics.” In this article the Spies laboratory addressed the regulation of the homologous genetic recombination, an enigmatic cellular mechanism responsible for the stability of our genomes and accurate repair of the most deleterious DNA damage. They combined the tools of biochemistry, chemical biology and single-molecule biophysics to determine the mechanism by which c-ABL kinase (and its oncogenic counterpart BCR-ABL) enhances the activity of human RAD51 recombinase, which catalyzes the central step in homologous recombination. Recent PhD, Shyamal Subramanyam, was first author of this work, which was a cornerstone of his dissertation.
Archive for September, 2016
|Grant Young, former Biochemistry undergraduate major, received “The Ponsetti Award for Research in Orthopedics” for his summer research as a U of Iowa medical student.|
The Department of Biochemistry held their 7th Annual Retreat on August 20, 2016, in the Coralville Public Library. The retreat featured 5 faculty talks and 34 poster presentations.
It was exciting to learn about all of the science happening in the Department! Congratulations to the winners of the various contests listed below.
Graduate Student Poster Competition:
1st Place: Lalita Oonthonpan (Taylor Lab) “Elucidating structure-function relationship of the mitochondrial pyruvate carrier”
2nd Place: Will Hacker (Elcock Lab) “Modeling the E. coli nucleoid subject to experimental restraints”
3rd Place: Mark Miller (Elcock Lab) “Re-parameterization of protein force fields guided by osmotic coefficient measurements from molecular dynamics simulations”
Postdoctoral/Medical Fellows and Research Staff Poster Competition:
Shyamal Subramanyam, Postdoc (M. Spies Lab) “Tyrosine phosphyorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamcs”
Undergraduate Poster Competition:
Rick Young (Wallrath Lab) “DNA damage associated with muscular dystrophy”
X-Scientist Theme Competition:
Sarah Hengel, aka Aqua Structure Girl (ASG) with her superpowers to shrink herself to the size of a water molecule, jump into protein solutions, and with her eyes shoot X-rays at the protein of interest for structural determination