Link: University of Iowa

Archive for June, 2010

Bridget Coughlin elevated to VP of Denver Science Museum

Friday, June 25th, 2010

Dr. Bridget Coughlin, a 1999 PhD with John Donelson and the human health curator at the Denver Museum of Nature and Science, has been promoted to Vice President of Strategic Partnerships & Programs at the museum. Her scientific career has taken her from Iowa City to Woods Hole and to a position as managing editor of PNAS. In addition to administrative responsibilities at the museum, she continues to curate exhibits and run an NIH-funded community-based participatory research laboratory on the genetics of human taste. She is also a current Livingston Fellow of the Bonfils Stanton Foundation, which supports the most outstanding leaders in the Colorado non-profit community.

How HIV-1 Tat hijacks pol II elongation

Wednesday, June 9th, 2010

HIV-1, the causative agent for AIDS, makes use of host enzymes to accomplish steps in viral replication including the production of full length viral mRNA. In new work published in today’s issue of Nature, the laboratories of Tahir Tahirov (Nebraska Medical Center) and David Price have determined the crystal structure of HIV-1 Tat in complex with human P-TEFb. The structure reveals conformational changes that could not have been anticipated from structures of Tat or P-TEFb alone and suggests a potentially druggable surface for inhibition of viral replication. The work was performed by Nigar Babayeva and Tahirov in Nebraska and by Katayoun Varzavand, Jeffrey Cooper, Stanley Sedore and Price in the Department and has also been featured in Cell.