The proliferating cell nuclear antigen (PCNA) is a trimeric, ring-shaped protein that slides along DNA to promote replication. When DNA is damaged, a replicative polymerase is replaced by a translesion polymerase in a process that involves addition of a single ubiquitin modification to each PCNA monomer. How this modification changes the appearance and function of PCNA was not understood until Todd Washington’s laboratory developed an ingenious trick. (more…)
Archive for March, 2010
Dr. Elisabeth Swain, a 1993 PhD from the University of Iowa and Lecturer in Biochemistry since 1996 has been reappointed to the faculty for an additional three year term. Named the UI College of Pharmacy “Non-Pharmacy Teacher of the Year” in 2005, Liz will take primary responsibility for teaching one-semester biochemistry survey courses for first year dental, pharmacy and physician assistant students. She will also offer 99:110, the one-semester introduction to biochemistry for undergraduates in the fall and develop the online version of this course to be offered in the spring. She and Todd Washington are redesigning 99:140, the biochemistry laboratory course, which she will offer next spring. A lecturer par excellence with students in five different colleges (liberal arts & sciences, engineering, dentistry, pharmacy and medicine), she is a true departmental all-star.
Biochemistry will be hosting a retirement party on June 12 to celebrate the career of Professor Alice Fulton, who will be transitioning to Emeritus status at the end of the academic year. A PhD from Brown University, Alice performed post-doctoral research with Chandler Fulton at Brandeis University and Sheldon Penman at Massachusetts Institute of Technology before coming to Iowa as an assistant professor in 1981. (more…)